U.S. Federal Route 278 runs east-west across Central Lafayette County. This is one of the main highways around Oxford. U.S. Rt. 278 passes through the following town in Lafayette County. Oxford
U.S. Rt. 278 is multi-plexed in Coahoma County. Mississippi State Route 6, through out Lafayette County.
EB U.S. Rt. 278/MS St Rt 6 east of the Lafayette/Panola County Line. EB U.S. Rt. 278/MS St Rt 6 south of Sardis Lake. EB U.S. Rt. 278/MS St Rt 6 west of Oxford. EB U.S. Rt. 278/MS St Rt 6 in Oxford. EB U.S. Rt. 278/MS St Rt 6 east of Oxford. EB U.S. Rt. 278/MS St Rt 6 near the Holly Springs National Forest. EB U.S. Rt. 278/MS St Rt 6 near Tula. EB U.S. Rt. 278/MS St Rt 6 west of the Lafayette Springs Area. EB U.S. Rt. 278/MS St Rt 6 near Lafayette Springs. EB U.S. Rt. 278/MS St Rt 6 near the Lafayette/Pontotoc County Line.