U.S. Federal Route 278 runs east-west across Panola County. This is one of the main highways in the Batesville Area. From Interstate 55, east to the Panola/Lafayette County Line, this is a four-lane divided highway. U.S. Rt. 278 passes through the following town in Panola County. Batesville
EB U.S. Rt. 278/MS St Rt 6 near the Panola/Quitman County Line. EB U.S. Rt. 278/MS St Rt 6 near the Tallahatchie River. EB U.S. Rt. 278/MS St Rt 6; NB MS St Rt 35 in Batesville. A junction marker on NB U.S. Rt. 51. EB U.S. Rt. 278/MS St Rt 6 in Batesville. EB U.S. Rt. 278/MS St Rt 6 east of I-55. EB U.S. Rt. 278/MS St Rt 6 near Sardis Lake. EB U.S. Rt. 278/MS St Rt 6 near the Panola/Lafayette County Line.