U.S. Federal Route 278 runs east-west across Quitman County. This runs from the Coahoma/Quitman County Line, near Lyon, to the Quitman/Panola County Line, near Crowder. U.S. Rt. 278 passes through the following towns in Quitman County. Marks
U.S. Rt. 278 is multi-plexed in Quitman County. Mississippi State Route 6, throughout Quitman County.
EB U.S. Rt. 278/MS St Rt 6 near the Coahoma/Quitman County Line. EB U.S. Rt. 278/MS St Rt 6 near Marks. A junction marker on NB MS St Rt 3. EB U.S. Rt. 278/MS St Rt 6 east of Marks. EB U.S. Rt. 278/MS St Rt 6 near the Quitman/Panola County Line.