U.S. Federal Route 78 runs in a angle across Union County. This runs from the Union/Pontotoc County Line, near Sherman, to the Union/Benton County Line, near Hickory Flats. U.S. Rt. 78 passes through the following town in Union County. New Albany
A junction marker on NB MS St Rt 15. WB U.S. Rt. 78 at New Albany. WB U.S. Rt. 78 near the Hell Creek W.M.A. WB U.S. Rt. 78 near Myrtle. WB U.S. Rt. 78 near the Union/Benton County Line.