Aya Brea is back in the game but not in New York anymore. She joins the FBI's Mitochondrion Investigation & Suppression Team (a.k.a. MIST). This time she battles against the Neo Mitochondria Creature (NMC). It seems that this time the monsters are under somebodys control and yup you guessed it, it's up to AYA to save the day. They track the source down to a shelter in Nevada. Aya meets Kyle, a police officer on her lone journey for the truth. Together they fight off the danger of the NMC and finds new facts about them.. and trys to stop there plans to take over the human race.....

The battle system is similar the Resident Evil's, you point the gun, and shoot with no ATB bar. There's not alot of weapons in the game but i dont really think that alot of weapons is needed anyways. Each type of gun has there own typ of ammo, ex: A Grenade Launcher will only take grenade rounds, very unlike the first Parasite Eve. You can also equip special items to you weapons, ex: an electric hammer can be eqiped onto a M4A4 Riffle and it will discharge electricity from it. You dont find weapons lying on the ground this time either, you either get them for free or buy them with bounus points (BP). BP are accumlated when you win a battle, you can also buy other things with BP like medicine and other usfull items. And of course it wouldn't be the same with Experience Points. you also get experience points when defeating an NMC. The points can then be traded for magic. there are a total of 12 magic to master, each magic can go up to lv. 3.

The control is really bad, even worse then resident evil's, although it's almost the same. The puzzles were extremly hard, thats why i made a puzzle key BUT overall i enjoyed playing this difficult game.