Medical Pharmacology Topics
| Preliminary Outline |
|
|
The afferent arteriol enters the glomerular capsule and breaks up into the glomerular network of capillaries across which filtration occurs. The capillaries merge into the efferent arteriole coming outof the glomerulus, which then breaks up into another capillary bed around the renal tubule. This second bed of capillaries play an important role in reclaiming most of what was filtered at the glomerulus.
There arent any drugs that effectively increase the rate of glomerular filtration to incre4ase uine ouput. Dopamine will cause increased renal blood flow which increases urine production a bit. Increasing GFR is generally not the best way to increase urine output. Rather we want to affect the reabsorptive effects of the nephron..
There are specific characteristics of the nephron with respect to normal physiology that can be altered to lter urine production. There are specific transporters for sodium along the nephron. What distinguishes the classes of drugs used yo alter urine flow is the selectivity for a transporter in a given part of the nephron.
The proximal convoluted tubules are responsible for reabsorbing 60% of the filtered sodium through generic Na+ transport, Na+ symport with a variety of organic solutes, Na+/H+ antiporter, and Na+/Cl- paracelular diffusion. Water is reabsorbed following the osmotic gradient created by Na+ through pores formed by the Aquaporin-1 protein. Na+/H+ antiporter is powered by the H+ gradient created by carbonic anhydrase. .
Continue
to "Diuretics" or take a quiz: [Q1].
Back to Basics:
Kidney Function and Anatomy
(Physiology)
Tubular Re-absorption
(Physiology)
Need more practice? Answer the review questions below.
Questions coming soon
