Pharmacology and Toxicology Quizzes
1- Subunits of heterotrimeric G-protein alpha, beta and gamma alpha and beta/gamma Ras, GNEF and GAP none of the above
2- Contains intrinsic GTPase activity alpha subunit beta/gamma complex GNEF GAP
3- Approximate size of gamma subunit 8 to 10 kD 20 to 30 kD 35 to 36 kD 39 to 46 kD
4- Nucleotide exchange in a heterotrimeric G-protein is catalyzed by activated receptor alpha subunit GAP GNEF
5- A G-protein participates in transduction if resistant analogs of GTP weaken ligand binding agonist binding is stimulated by GTP either pertussin toxin or cholera toxin block the effect all of the above
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Answers:
1- Subunits of heterotrimeric G-protein Answer: alpha, beta and gamma
2- Contains intrinsic GTPase activity Answer: alpha subunit
3- Approximate size of gamma subunit Answer: 8 to 10 kD
4- Nucleotide exchange in a heterotrimeric G-protein is catalyzed by Answer: activated receptor
5- A G-protein participates in transduction if Answer: resistant analogs of GTP weaken ligand binding