Pharmacology and Toxicology Quizzes
1- G-proteins transduce a signal from a receptor initiate a signaling cascade catalyze the synthesis of effector molecules all of the above
2- Subunits of a small G-protein alpha, beta and gamma alpha and beta/gamma Ras, GNEF and GAP none of the above
3- Most often binds to an effector alpha subunit beta subunit gamma subunit beta/gamma complex
4- Needed by small G-proteins to activate their intrinsic GTPase activity GAP GNEF alpha subunit beta/gamma complex
5- Heterotrimeric G-proteins dissociate into alpha, beta and gamma subunits when active remain bound to effector after inactivation when active, their receptor has low affinity all of the above
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Answers:
1- G-proteins Answer: initiate a signaling cascade
2- Subunits of a small G-protein Answer: none of the above (has no subunits!)
3- Most often binds to an effector Answer: alpha subunit
4- Needed by small G-proteins to activate their intrinsic GTPase activity Answer: GAP
5- Heterotrimeric G-proteins Answer: when active, their receptor has low affinity