Pharmacology and Toxicology Quizzes  

G-proteins Quiz 6

1- Not a MAP kinase
MAPKKK
ERKS
JNKS
p-38


2- Activated by GNEFs
Ras
small G-proteins
alpha subunit
the first two are correct


3- A G-protein participates in transduction if
resistant GTP analogs increase ligand binding
GTP binding is stimulated by agonist
effector activity is altered by GDP
Pertussin toxin augments effect


4- Binds GTP/GDP
alpha subunit
beta subunit
gamma subunit
GNEF


5- G-proteins
slowly hydrolyze bound GTP
catalyze their own inactivation
may need assistance for inactivation
all of the above


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Answers:

1- Not a MAP kinase
Answer: MAPKKK


2- Activated by GNEFs
Answer: the first two are correct (Ras AND small G-proteins)


3- A G-protein participates in transduction if
Answer: GTP binding is stimulated by agonist


4- Binds GTP/GDP
Answer: alpha subunit


5- G-proteins
Answer: all of the above (slowly hydrolyze bound GTP AND catalyze their own inactivation AND may need assistance for inactivation)