Pharmacology and Toxicology Quizzes
1- Not a MAP kinase MAPKKK ERKS JNKS p-38
2- Activated by GNEFs Ras small G-proteins alpha subunit the first two are correct
3- A G-protein participates in transduction if resistant GTP analogs increase ligand binding GTP binding is stimulated by agonist effector activity is altered by GDP Pertussin toxin augments effect
4- Binds GTP/GDP alpha subunit beta subunit gamma subunit GNEF
5- G-proteins slowly hydrolyze bound GTP catalyze their own inactivation may need assistance for inactivation all of the above
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Answers:
1- Not a MAP kinase Answer: MAPKKK
2- Activated by GNEFs Answer: the first two are correct (Ras AND small G-proteins)
3- A G-protein participates in transduction if Answer: GTP binding is stimulated by agonist
4- Binds GTP/GDP Answer: alpha subunit
5- G-proteins Answer: all of the above (slowly hydrolyze bound GTP AND catalyze their own inactivation AND may need assistance for inactivation)