Pharmacology and Toxicology Quizzes
1- Gi activation leads to cAMP formation inhibits adenylyl cyclase is due to phosphorylation none of the above
2- Adenylyl may be activated by Gs beta/gama complex alpha subunit all of the above
3- After binding cAMP, PKA will look like (R=regulatory subunit, C=catalytic subunit, numbering like a molecular formula): R2(cAMP)4 + 2C 2RcAMP2 + 2C 2RcAMP + 2CcAMP 2R + C2(cAMP)4
4- Not a regulator of the cAMP/PKA cascade GI phosphodiesterase cAMP analogs adenylyl cyclase
5- When active, the catalytic units of PKA dephosphorylate adenylyl cyclase phosphorylate CREB bind transcription factors phosphorylate tyrosine residues
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Answers:
1- GI activation Answer: inhibits adenylyl cyclase
2- Adenylyl may be activated by Answer: all of the above (Gs AND beta/gama complex AND alpha subunit)
3- After binding cAMP, PKA will look like (R=regulatory subunit, C=catalytic subunit, numbering like a molecular formula): Answer: R2(cAMP)4 + 2C
4- Not a regulator of the cAMP/PKA cascade Answer: adenylyl cyclase
5- When active, the catalytic units of PKA Answer: phosphorylate CREB