1- Adenylyl cyclase is inactivated by
Gi
alpha subunit
beta/gamma complex
the first two are correct

2- Adenylyl cyclase has
a short intracellular C-terminus
6 hydrophobic stretches
12 transmembrane helices
two extracellular catalytic domains

3- Not a fate of cAMP
degradation
opening ion channels
kinase activation
transcription factor activation

4- cAMP activates
PKA
phosphodiesterase
CREB
all of the above

5- CREB binds to and activates
transcription factors
proteins containing Ser or Thr
PKA
all of the above

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Answers:

1- Adenylyl cyclase is inactivated by
Answer: the first two are correct (is inactivated by the alpha subunit of a GI)

2- Adenylyl cyclase has
Answer: 12 transmembrane helices

3- Not a fate of cAMP
Answer: transcription factor activation

4- cAMP activates
Answer: PKA

5- CREB binds to and activates
Answer: transcription factors