Pharmacology and Toxicology Quizzes  

cGMP/PKG System and Nitric Oxide Quiz 2

1- Soluble guanylyl cyclases
contain heme groups
have alpha-1 and beta-1 subunits
are homodimers
the first two are correct


2- Membrane bound guanylyl cyclases are activated by
atrial natriuretic peptide
Ca2+
NO
G-proteins


3- PKA phosphorylates
tyrosine residues
serine or threonine residues
phosphodiesterases
all of the above


4- cGMP depolarizes rod cells by
binding Na+ channels
increasing phosphodiesterase activity
decreasing NO levels
none of the above


5- Not a form of NOS
endothelial
epithelial
neuronal
inducible


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Answers:

1- Soluble guanylyl cyclases
Answer: the first two are correct (contain heme groups AND have alpha-1 and beta-1 subunits)


2- Membrane bound guanylyl cyclases are activated by
Answer: atrial natriuretic peptide


3- PKA phosphorylates
Answer: serine or threonine residues


4- cGMP demoralizes rod cells by
Answer: binding Na+ channels


5- Not a form of NOS
Answer: epithelial