1- Soluble guanylyl cyclases
contain heme groups
are activated by guanylils
are homodimers
all of the above

2- Membrane-bound guanylyl cyclases have dimers with
ligand binding domains
transmembrane domains
C-terminus cyclase domains
all of the above

3- Not a regulator of the cGMP/PKG transduction cascade
nitric oxide
PKG inhibitors
ion channels
phosphodiesterase inhibitors

4- Nitric oxide
increases membrane-bound guanylyl cyclase activity
increases soluble guanylyl cyclase activity
its synthesis is activated by cGMP
all of the above

5- Reaction catalyzed by NOS
arginine NO + H2O + citrate
arginine NO + citrulline
citrulline NO + arginine
citrulline NO + H2O + arginase

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Answers:

1- Soluble guanylyl cyclases
Answer: contain heme groups

2- Membrane-bound guanylyl cyclases have dimers with
Answer: all of the above (ligand binding domains AND transmembrane domains AND C-terminus cyclase domains)

3- Not a regulator of the cGMP/PKG transduction cascade
Answer: ion channels

4- Nitric oxide
Answer: increases soluble guanylyl cyclase activity

5- Reaction catalyzed by NOS
Answer: arginine NO + citrulline