Pharmacology and Toxicology Quizzes  

Lipases and IP3 Quiz 3

1- Phospholipase C
generates PIP2
generates DAG
hydrolyzes IP3
all of the above


2- PLCgamma is activated by
platelet-derived growth factor
tyrosine phosphorylation
Gq - protein
the first two are correct


3- Enzyme that cleaves at the red line

PLA2
PLC
PLD
PLA2 and diacylglycerol lipase


4- IP3 is catabolized by
inositol
phosphatase
phosophodiesterase
none the above


5- Not an IP3 receptor domain
N-terminus IP3 binding site
ATP-binding catalytic domain
regulatory domain with phosphorylation sites
six transmembrane domain


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Answers:

1- Phospholipase C
Answer: generates DAG


2- PLCgamma is activated by
Answer: the first two are correct (platelet-derived growth factor AND tyrosine phosphorylation)


3- Enzyme that cleaves at the red line

Answer: PLA2 and diacylglycerol lipase


4- IP3 is catabolized by
Answer: phosphatase


5- Not an IP3 receptor domain
Answer: ATP-binding catalytic domain