Pharmacology and Toxicology Quizzes
1- PLA2 isozymes soluble forms are more important are activated by PKC are activated by steroids all of the above
2- Lysophosphatidic acid is released from DAG by PLA2 acts as a first messenger activates EDG receptors all of the above
3- Arachidonic acid is metabolized by lipoxygenases into prostaglandins thromboxanes leukotrienes EETS
4- Inducible COX is not inhibited by aspirin is inhibited by selective inhibitors generates leukotrienes the first two are correct
5- Regulates vasodilation arachidonic acid HETES EETS none of the above
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Answers:
1- PLA2 isozymes Answer: are activated by PKC
2- Lysophosphatidic acid Answer: all of the above (is released from DAG by PLA2 AND acts as a first messenger AND activates EDG receptors)
3- Arachidonic acid is metabolized by lipoxygenases into Answer: leukotrienes
4- Inducible COX Answer: is inhibited by selective inhibitors
5- Regulates vasodilation Answer: EETS