Pharmacology and Toxicology Quizzes  

Phospholipase A2 and Arachidonic Acid Quiz 3

1- PLA2 are directly activated by
PKC
PKC and Ca2+
PKG
PKG and Ca2+


2- EDGs are
G-protein receptors
second messengers
activated by DAG
all of the above


3- Arachidonic acid is metabolized by cytochrome P450 into
prostaglandins
thromboxanes
leukotrienes
EETS


4- Makes HPETES from arachidonic acid
cyclooxygenases
lipoxygenases
P450
the first two are correct


5- Lipoxygenases require
Ca2+

ATP

hydroperoxy acid

all of the above


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Answers:

1- PLA2 are directly activated by
Answer: PKC and Ca2+


2- EDGs are
Answer: G-protein receptors


3- Arachidonic acid is metabolized by cytochrome P450 into
Answer: EETS


4- Makes HPETES from arachidonic acid
Answer: lipoxygenases


5- Lipoxygenases require
Answer: all of the above (Ca2+
AND ATP AND hydroperoxy acid)