Pharmacology and Toxicology Quizzes  

Phospholipase A2 and Arachidonic Acid Quiz 3

1- PLA2 hydrolyzes
arachidonic acid
phosphatidic acid
leukotrienes
all of the above


2- Not a fate of arachidonic acid
reincorporated into plasma membrane
metabolized by cyclooxygenases
metabolized by P4540
none of the above


3- Cyclooxygenase isozymes
COX2 and COX3
inducible and constitutive
lipoxygenase and COX1
none of the above


4- 12'-lipoxygenase
is found in the nervous system
produces a second messenger
produces prostaglandins
the first two are correct


5- PLA2 is directly activated by
Ca2+

PLC

PLD

all of the above


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Answers:

1- PLA2 hydrolyzes
Answer: phosphatidic acid


2- Not a fate of arachidonic acid
Answer: none of the above (arachidonic acid may be reincorporated into plasma membrane OR metabolized by cyclooxygenases OR metabolized by P4540)


3- Cyclooxygenase isozymes
Answer: inducible and constitutive


4- 12'-lipoxygenase
Answer: the first two are correct (is found in the nervous system AND produces a second messenger)


5- PLA2 is directly activated by
Answer: Ca2+