Pharmacology and Toxicology Quizzes
1- PLA2 hydrolyzes arachidonic acid phosphatidic acid leukotrienes all of the above
2- Not a fate of arachidonic acid reincorporated into plasma membrane metabolized by cyclooxygenases metabolized by P4540 none of the above
3- Cyclooxygenase isozymes COX2 and COX3 inducible and constitutive lipoxygenase and COX1 none of the above
4- 12'-lipoxygenase is found in the nervous system produces a second messenger produces prostaglandins the first two are correct
5- PLA2 is directly activated by Ca2+ PLC PLD all of the above
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Answers:
1- PLA2 hydrolyzes Answer: phosphatidic acid
2- Not a fate of arachidonic acid Answer: none of the above (arachidonic acid may be reincorporated into plasma membrane OR metabolized by cyclooxygenases OR metabolized by P4540)
3- Cyclooxygenase isozymes Answer: inducible and constitutive
4- 12'-lipoxygenase Answer: the first two are correct (is found in the nervous system AND produces a second messenger)
5- PLA2 is directly activated by Answer: Ca2+