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Fluoride in Water

Threads - Fluoride Protection in Water Consumption, Chemicals of Concern in Water

On 22/5/2003, Warren Davis wrote:

My wife and I mainly consume bottled water. For my part, I was incapable of consuming Perth tap water due to an extreme adverse reaction whereby my throat swelled up causing me considerable pain and discomfort. Hence my aversion to treated tap water, at least in Perth. I hasten to add that in my 28 years prior existence in Melbourne I never experienced problems consuming tap water.

I have since relocated to Sydney as of December 2002 and married in the following month. Recently, my wife, aged 26, has been the recipient of her mother's concerns that the consumption of bottled drinking water (to the exclusion of tap water) leaves us, but in particular, my wife, exposed to the lack of fluoride protection, especially at a time when my wife and I are intending to achieve a pregnancy. The premise of my mother-in-law is that tooth deterioration and decay can be severe during pregnancy, from which the concern stems with regards the relative absence of  fluoride as a result of our consumption of bottled water.

My recollection from my own parents many years ago was that medical results from decades long studies in other countries demonstrated that fluoride included in drinking water has led to various bone deformities in some northern European countries.

I invite members from the list to offer disinterested comment and evaluation on the matter I have raised in relation to the concerns my mother-in-law has justifiably raised with my wife. References to various scientific data and findings will be greatly appreciated.

Toby Fiander replied:

Until recently, it was generally held that fluoride in drinking water pervaded the food chain sufficiently that it did not matter if any individual drank water directly or not.  However, control of water quality in manufacture is much more complete than it used to be and fluoride is probably excluded in some processes.  So, drinking water becomes a more important source of fluoride.

Some recent findings about the prevalence of child tooth decay in Sydney indicate that there is a possibility that drinking bottled water is having a deleterious effect on dental health in children.   I think it is a long bow to draw to directly connect the rates of tooth decay, which are on the rise, with consumption of bottled water, but that inference was made in the study conclusions, I understand.  There was no distinction made between children drinking bottled water and their pregnant mothers drinking it - it was pretty audacious making any conclusion, I thought..  There are no other recent Australian data of which I know.

I can understand why there might be some tendency to drink bottled water in Perth, in spite of the poor record of bottled waters generally.  Sydney's water has a unique taste, like every other water, which is probably unpleasant when you first meet it, but it has proven to be very safe in epidemiological terms over a long period of time.  Water supply standards have also risen, in spite of scares in the press, reported presence of various organisms and the like - generally, testing is more sensitive and there is a greater awareness of what is in water supplied.  The press tend to leave out the good news.

It would be possible to continue to drink a non-fluoridated water (like that in bottles or from a bore) and to take fluoride tablets.  I am the product of my mother's strategy which was very similar to this, because there was no fluoride in water supply when I grew up.  My pharmacist mother was aware of its importance and took fluoride tablets, when she wasn't vomiting them up again in the mornings or too busy to remember to take them anyway.  The majority of my teeth are filled and I am about to lose a tooth to decay.  My sister, who is five years my junior grew up with fluoridated water and still (at age 44) has few fillings in her teeth - there were none at all until she was in her 30s.  I think, even on the limited data, that the likely outcome from each strategy is fairly clear.

However, it is probably relatively simple for blokes to theorise about it all - we will never be pregnant.  I don't think that starting to drink a new water at the same time as coping with morning sickness would be a good strategy.

Also, what people eat and drink has more than just a logical element to it.

Geoff Pain added:

I drink only rain water collected at my home (with associated risks). But I occasionally drink tea and use fluoridated toothpaste, careful not to swallow.

You might like to consider evidence of brain damage caused by fluoride to the developing foetus and weaning mammal.

In 1995 and 1996, two epidemiological studies from China revealed low IQ associated with fluoride in public drinking water (published in the journal Fluoride by X S Li and L B Zhao).

I am looking at the possibility that fluoride might be a factor in thyroid disease (recent reports in the media that 11% of Australian children have thyroid problems) and the link between thyroid and depression. I'm also following the possibility that apparent increase in attention hyperactivity deficit disorder could be linked to introduction of fluoride.

In 1998, the adverse effect of 2 ppm sodium fluoride on rats was published by J A Varner et al in Brain Research 784, pp284-98. I don't have the full paper but they observed chromatin clumping, enhanced protein staining, pyknosis, vacuolation, presence of ghost-like cells and decreased neuronal density in adult rats exposed to 1 ppm fluoride for 52 weeks.(cited in Fluoride 35(1) 12-21 - see below).

This study found that fluoride enhanced aluminium-induced neural degeneration in rats and that the "surprising" result came from the NaF controls.

In 1995 Dr Phyllis Mullenix published (in Neurotoxicology and Teratology Volume 17 No 2 pp 169-77) fluoride-induced behavioural disruptions and predicted effects in the hippocampus. There was a distinct diffrence between males and females in the effects.

In 2002, a study of brain damage caused by fluoride at doses of 100 ppm was published in the journal Fluoride Vol 35 No 1, pp 12-21 by Y M Shivarajashankara et al with excellent photomicrographs of hippocampus, motor cortex, cerebellum and amygdala which convince me that fluoride should be banned from public drinking supplies.

It might interest you to know that the Western Australian government removes fluoride from some artesian water supplies such as Quindalup.

If your wife drinks tea, she will of course receive a pleasant tasting dose of fluoride.

Please let me know if you get any further scientific response to you important question.

Toby Fiander replied:

Where to start...?

The drinking water concentrations in major capital cities are generally <0.8mg/L, which is about the natural concentrations in lots of places in the world and less than most of the "low fluoride" cases in the Chinese literature quoted.  In his email, Geoff Pain mentions nothing about the concentrations that are being looked at in the Chinese studies he quotes.

>  You might like to consider evidence of brain damage caused
>  by fluoride to the developing foetus and weaning mammal.

>  In 1995 and 1996, two epidemiological studies from China
>  revealed low IQ associated with fluoride in public drinking
>  water (published in the journal Fluoride by X S Li and L B Zhao).

The concentrations looked at in this study are generally above 3mg/L, which is quite high.  There was no check for other influencing factors, and the only conclusion was, in any case, that further study is probably necessary.  ... hardly surprising given the size of the samples.  Also, as noted above, the children of the low fluoride area in this study had drinking water which is comparable to the level of fluoride in Sydney drinking water.

> I am looking at the possibility that fluoride might be a factor
>  in thyroid disease (recent reports in the media that 11% of
>  Australian children have thyroid problems) and the link
>  between thyroid and depression. I'm also following the
>  possibility that apparent increase in attention hyperactivity
>  deficit disorder could be linked to introduction of fluoride.

I am not aware of Australian literature on this.  Any effect seems more likely to be lethargy and goitre than hyperactivity, but I would like to see some local evidence one way or another.

There is some suggestion in the same Chinese literature that there might be a thyroid effect from high fluoride in drinking water (>4mg/L).

Australian soils are generally deficient in iodine - this is why iodised salt was introduced to Australia.  If Geoff is referring to the possible aggravation of iodine deficiency by fluoride, then once again, you need to look at the concentrations involved.  A supplement of both is probably a good idea, so always buy iodised salt if you have a choice and drink plenty of good capital city tap water after you have it in moderation on your meal.

>  In 2002, a study of brain damage caused by fluoride at doses
>  of 100 ppm was published in the journal Fluoride Vol 35
>  No 1, pp 12-21 by Y M Shivarajashankara et al with excellent
>  photomicrographs of hippocampus, motor cortex, cerebellum
>  and amygdala which convince me that fluoride should be
>  banned from public drinking supplies.

Why?  100ppm is about 120 times what is in drinking water in capital cities.

If you take 120 times the recommended daily dose to Vitamin A, you will probably die or at least be quite sick, but if you have none you will die also.  It is much the same with a lot of things.

Using the same logic it would be better to ban potatoes because someone could poison themselves by having 200kg of them for dinner.

> In 1995 Dr Phyllis Mullenix published (in Neurotoxicology
>  and Teratology Volume 17 No 2 pp 169-77) fluoride-induced
>  behavioural disruptions and predicted effects in the
>  hippocampus. There was a distinct difference between males
>  and females in the effects.

Even supposing you take Mullenix seriously, Mullinex deliberately induced fluorosis in her animals, which means probably having drinking water with a concentration of more than 5mg/L and even she spoke only the effects of  "excessive fluoridation" in the USA - see comments at the end about standards.

>  In 1998, the adverse effect of 2 ppm sodium fluoride on rats
>  was published by J A Varner et al in Brain Research 784,
>  pp284-98. I don't have the full paper but they observed
>  chromatin clumping, enhanced protein staining, pyknosis,
>  vacuolation, presence of ghost-like cells and decreased
>  neuronal density in adult rats exposed to 1 ppm fluoride for
>  52 weeks.(cited in Fluoride 35(1) 12-21 - see below).
>
> This study found that fluoride enhanced aluminium-induced
>  neural degeneration in rats and that the "surprising" result
>  came from the NaF controls.

I have a copy of the text.  Julie Varner is a research assistant at Lineberry Associates and was at Duke University.  Although she had limited experience, the work is genuine.  The principal finding is that, not surprisingly, more work is needed, not least on the proprietary rat food product that the laboratory rats were eating, which has an unknown content of fluoride and is mentioned in the paper.

> It might interest you to know that the Western Australian
>  government removes fluoride from some artesian water
>  supplies such as Quindalup.

The groundwater supply (from the Leederville aquifer) has high iron and fluoride.  The treatment system removes iron as well.  An activated alumina process is used for the fluoride, I think, and reduces the fluoride content from >5mg/L to about 1mg/L, as near as anyone could tell me when I inquired.

NHMRC guidelines for fluoride in drinking water is 1.5mg/L, which is about the same as in seawater.  The US standard is 4mg/L, which is probably why a lot of the noise about this matter seems to originate from the US..

Gerald Cairnes commented:

As a kid in Scotland during the war I and my brothers had heaps of cavities yet sweet things were not in plentiful supply. After the introduction of fluoride in water and toothpaste I have had only reconstructive fillings etc.

Our kids grew up on the farm where we drank filtered rain water and received sodium fluoride tablets and their teeth are excellent except for one tooth my daughter has that never produced it's own enamel and had to be crowned. Compared to my generation this is a fantastic result but of course 2 observations don't make statistical significance.

On 6/6/2003, Geoff Pain wrote:

Maybe you can ask around the conference on the following idea.

It has recently been reported (saw it on TV) that there is a latitude effect, so far unexplained, in the prevalence of Multiple Sclerosis in Australia, where people in Tasmania seem 7 times more at risk than north Queenslanders.

Fluoride has been shown to cause demyelination in animals, so I wonder if the fluoride intake is a possible cause of the observed latitude effect.

A medico at UWA has just announced that tea drinkers have lower blood pressure than others and fluoride, abundant in tea,  is known to cause hypotension.

I wonder if Australians drink more tea as we move South?

Toby Fiander replied:

The latitude effect you indicate for MS is real, and fascinating. Australia is one of the easier places to see it, apparently.

The difference in fluoridation don't amount to much as you travel south, and if there was a link with fluoridation, you would expect to see MS in places where fluoride was naturally more than in any of the Australian capital city water supplies (which, BTW, is quite a lot of the world).  Some of the data on MS, as I understand it anyway, also predates fluoridation, which makes fluoridation an unlikely explanation.

Geoff, as you no doubt know, your concern about concentrations of fluoride are shared by NHMRC, because the difference between a therapeutic dose and an overdose is smaller for fluoride than for most other beneficial quantities found in water.  The NHMRC view either is, or is about to be, that anything under 1mg/L (was 1.5mg/L) is not only safe but beneficial.  [NHMRC actually think higher concentrations would be OK, but is conscious of minority concerns, among other things].

As I write the equivalent standard in the US is still 4mg/L, and at that rate there is where there is probably a legitimate complaint. at concentrations above 4mg/L, the Chinese work to which you have previously referred shows that there are nervous systems responses to fluoride in water.  But, this concentration is nothing like any public water supply in Australia, due to the NHMRC standard and even the control for comparison (ie.  the cases labelled in the Chinese work as "low fluoride") are at the same sort of level as most capital water supplies in Australia.

Anyway, I will put your thoughts to a group of people I regularly meet with about water supply and see what I get in return... I suspect I know, but I will put the matter fairly, because there is an explanation for the effect of latitude on MS and it needs to get found.

Geoff Pain posted:

For those interested in recent developments in fluoride toxicology, have a look at Professor Connett's bibliography on just one area.


FLUORIDE & BONE: An Annotated
Bibliography
http://www.slweb.org/fluoride-bone.html