Homeopathy
Thread - Catalytic Cracker for the Pigeon Loft,
Homeopathy, The Meaning of Sarcode,
On 28/3/2003, Donald Lang replied to a
post by Ray:
>
You betcha Donald.
> Catalyst next week re: Homeopathy is a go.
> Ray
OK. Errrm!
OK. I did bring in the subject of homeopathy looking for list
reaction. And yes, I was being [just a bit] frivolous. But...
Those who were
around on this list will all remember Rebecca who came to reform us and
left [apparently] in silence. There were several dozen postings in less
than a week. I think the response nearest to encouraging said something
like: "Well it is still obviously rubbish, but if mainline medicine
gave me no hope and I still wanted to live I would grab anything
labelled a 'lifeline'."
'Catalyst' is I
think the local show that most people would have to nominate as closest
to science based TV. I suspect that some of us should watch it to see
what they make of the subject of homeopathy. I will admit to hoping
that our watchers find themselves cheering as Catalyst
investigators undertake a remorseless quest for evidence. The
pessimistic part of my mind thinks that our watchers will watch
in dismay as a parade of untruths and anecdotal 'cures' is presented as
evidence.
Given a chance
we need to discuss how to cheer on the good guys. If said good guys do
not get star billing we need to discuss how to make a flagship stop
carrying a flag of convenience.
It occurs to me
that there is science content in the label. A flag of convenience is
one that flies over an outhouse. Given any encouragement, I am sure
Toby will explain that there is a lot of good science and technology
associated with outhouses. It can be claimed that we have become too
fussy about smells associated with the processes therein. Perhaps we
should all accept the smells near the building. OK, but.....When
science is presented, there should be no outhouse smells coming off the
printed page, at least in the current stage of technology.
Podargus
replied:
>
OK. Errrm! OK. I did bring in the subject of homeopathy looking
for list
> reaction. And yes, I was being [just a bit] frivolous.
And
I replied in kind.
>
But...
> Those who were around on this list will all remember Rebecca who
came to
> reform us and left [apparently] in silence. There were several
dozen
> postings in less than a week. I think the response nearest to
encouraging
> said something like: "Well it is still obviously rubbish, but if
mainline
> medicine gave me no hope and I still wanted to live I would grab
anything
> labelled a 'lifeline'."
As
my wife suffered from severe arthritis for some 30 years and died from
a brain cancer I am more than sensible to this argument. However
it is this very vulnerability for such people and there families that
is at the root of the problem.
I
am having a battle with my local U3A (University of the Third Age- Old
Farts). They wanted to run a course in reflexology, something
that made me rise to the bait. I half won the battle in that such
things will have to go to the executive for decision in the future,
and/or be dealt in a comparative manner, in the same way as we already
deal with religion and politics. In this particular case I was
chuffed to find that it failed anyway from lack of participants.
My
main contention was that not only did these 'alt med' beliefs have
almost no credibility, we were a particularly vulnerable group, most
members experiencing deteriorating health with age.
>
'Catalyst' is I think the local show that most people would have to
nominate
> as closest to science based TV. I suspect that some of us should
watch it to
> see what they make of the subject of homeopathy. I will admit to
hoping that
> our watchers find themselves cheering as Catalyst
investigators undertake a
> remorseless quest for evidence. The pessimistic part of my mind
thinks that
> our watchers will watch in dismay as a parade of untruths and
anecdotal
> 'cures' is presented as evidence.
In
spite of having a science unit Aunty is giving a good run to a lot of
this pseudo science guff of late. 'Bush Telegraph' gave extensive
air time to a certain Hugh Lovel whom I have mentioned before.
The journalist, Elisha Brown (who I have had the odd interview with
-all my interviews are odd;-)) did sound sceptical, but there was no
countering of the nonsense. I
did
ask before the interview went to air for there to be at least a counter
view put, but to no avail. Our local ABC had one of its 'true
believers' interview a palm reader at great length, again with no
comment.
>
Given a chance we need to discuss how to cheer on the good guys. If said
> good guys do not get star billing we need to discuss how to make a
flagship
> stop carrying a flag of convenience.
>
> It occurs to me that there is science content in the label. A flag
of
> convenience is one that flies over an outhouse. Given any
encouragement, I
> am sure Toby will explain that there is a lot of good science and
technology
> associated with outhouses. It can be claimed that we have become
too fussy
> about smells associated with the processes therein. Perhaps we
should all
> accept the smells near the building. OK, but.....When science is
presented,
> there should be no outhouse smells coming off the printed page, at
least in
> the current stage of technology.
It
seems to me that there is always a problem in presenting any of this
pseudo science to the general public. It is seldom, if ever
possible to present it in such a fashion that the pseudo science
explanation is not a credible alternative to people not trained in
critical thinking. The recent Catalyst story presented by Paul
Willis on the 'Yowie' is a case in point. The scientific explanation of
the tree damage was attributed to black cockatoos. However there
was no footage of this happening, which left the alternative
explanation of yowie damage probably just as credible in the
public mind.
I'll
make a prediction that the upcoming segment on homeopathy will present
a case in which X disease did not respond to Y treatment but after
taking Z alternative it cleared up.
Natterers
will of course know that this could be attributed to the complaint
being cured despite any treatment, being cured by Y after an
appropriate time or possibly by Z. They will also realise that it
is only one case out of zillions and just may not have anything to do
with any of the above. But 'general public' will not see it that
way.
The
general public sees anecdotal evidence as real evidence, not just as a
possible lead for further research.
David Maddern
answered:
>From
my point of view there is something needed to be said about what
is scientific and what isn't.
When testing
some treatment on human subjects
Researchers
eschew the Placebo Effect with gusto because it is not an authentic
effect of the treatment and thus must be excluded. I think I can
remember it quoted that the effect can be up to 30%. It would not
be exaggerating to say researchers do cartwheels to exclude it, and
greatly increase the size of the test (randomised, double-blind etc) .
However, they
then seem to deride it still when talking about their drugs effect in
the body.
This is an
error. Placebo Effect can be a positive feature of the system,
and works regardless of the efficacy of the treatment being applied.
So hard edged
science that religiously reject things such as reflexology run the risk
of denying peoples belief with their own belief which has no higher
validity.
Laughter and
happiness also have an effect! What says that participants wont enjoy
their participation in such courses, and have social interaction that
in its entirety is fairly fundamental to us gregarious beings.
Chris
Lawson responded:
At
23:19 28/03/03 +1100, Donald Lang wrote:
>'Catalyst'
is I think the local show that most people would have to nominate
>as closest to science based TV. I suspect that some of us should
watch it to
>see what they make of the subject of homeopathy. I will admit to
hoping that
>our watchers find themselves cheering as Catalyst
investigators undertake a
>remorseless quest for evidence. The pessimistic part of my mind
thinks that
>our watchers will watch in dismay as a parade of untruths and
anecdotal
>'cures' is presented as
>evidence.
To
be fair to Catalyst, if they want to present both sides of the story
(and one assumes they do given they've devoted two episodes to it),
then most of the evidence for homeopathy will have to be anecdotal. I
have no objection to this. But my suspicion, having tuned into Catalyst
once or twice, is that they will present the anecdotal evidence only
briefly, and
then
do something even worse: they will go talk to one of the "scientific"
homeopath supporters and allow the guy to present the best trials they
have as if they are convincing...even though I don't know anyone at all
with any solid understanding of stats who thinks the pro-homeopathy
papers are of any real value. But nevertheless, this will be presented
as strong evidence for homeopathy, and because the report will not
focus on scientific methodology (this being a boring subject to most
viewers), the evidence will be left to stand uncriticised except by
skeptics who will be made to look bitter and vindictive by simply
insisting on decent scientific standards.
Having
done this, the report will then look at the scientific basis for
homeopathy and present the evidence that it completely flies in the
face of the last two hundred years of chemistry research. This will
then be presented as a choice between homeopathy being ineffective, or
the vanguard of an exciting new science. It will not be explained to
viewers that "exciting new fields of science" still have to incorporate
existing evidence. Einstein didn't overthrow Newton's findings, he
showed that they only applied to a limited domain. But homeopaths ask
us to completely reject all the existing knowledge of chemistry -- not
the same thing.
Finally,
the audience will be asked to make its own decision. Which is fine, but
to my mind this always assumes the audience has been given a fair
approximation of the best available evidence. Unfortunately, the
Catalyst report will not be interested in giving a summary of the best
available evidence, but will instead have strived for the common
journalistic goal of "even time." This is a noble and important
principle of journalism, but it should not be universally applied.
There are times when one side of a
debate
simply doesn't deserve to be treated on an equal basis -- an extreme
example would be Holocaust revisionists. They do not deserve equal time
with mainstream historians. Homeopathy is obviously not as extreme an
example, but it does deserve a more critical appraisal than it is
likely to receive.
and:
At
17:05 29/03/03 +1030, David Maddern wrote:
>However,
they then seem to deride it still when talking about their drugs
>effect in the body.
>
>This is an error. Placebo Effect can be a positive feature of
the system,
>and works regardless of the efficacy of the treatment being applied.
David,
with due respect this is simply not true. Scientists and doctors don't
want to do away with the placebo effect. They want to make sure their
treatments work better than placebo. There's a big difference.
It
is well known, for instance, that modern anti-depressants take at least
a week to make any difference to mood, and more usually a full month,
but it is also known that many people who start taking anti-depressants
feel better almost immediately -- because they are doing something and
because they often have a hope of improvement that they may not have
perceived prior to therapy. Nobody wants to stop this benefit, even
though it is a placebo effect.
On 2/4/2003,
David Allen wrote:
There was an
interview, this morning. on Qld AM radio with the producer of Catalyst.
Evidently the forthcoming program is a Horizon production and it was
mentioned that it was done in an attempt to win Randi's $1,000,000.
We were warned
that there was a (were some) surprises in store but I haven't heard of
the prize being paid even though it went to air in the UK in November.
http://www.bbc.co.uk/science/horizon/2002/homeopathy.shtml
I think I'm more
looking forward to this place over the next couple of weeks than to the
program.
Chris
Lawson replied:
This
link you posted has a major spoiler: it gives the final result of the
study. I will not discuss this any further because there are many
people on this list who would prefer to see the story unfold next week.
But
I would point out one MAJOR error in the Horizon summary page (this has
no spoilers, so I'm happy to reproduce it).
The
page says: "Could the beneficial effects of homeopathy be entirely due
to the placebo effect? If so, then homeopathy ought not to work on
babies or animals, who have no knowledge that they are taking a
medicine. Yet many people are convinced that it does."
I'm
sorry, but this is wrong, wrong, wrong.
As
I've already discussed earlier, the placebo effect works not just
through the *test subject's* awareness, but the parents, colleagues,
friends of the test subject, and also the researchers themselves. That
is why we do *double-blind* studies and not single-blind studies. This
is a really elemental error, and does not do much for my faith in
Horizon.
I
note with particular irritation that this is discussed quite well in
the "Q&A" webpage, but the fallacy is in the summary and the full
transcript of the story. I mean, really. Given that the journalist had
gone to the trouble of interviewing quite a few scientists, I would
have thought this would have been cleared up by the time the story was
being written for broadcast.
In
the main story, the journalist interviews a "homeopathic vet" who says
this same thing about animals: "when you see a positive result in a
horse or a dog that to me is the ultimate proof that homeopathy is not
placebo", but then instead of *answering* the challenge, the
journalist just does one of those segues, "But Mark's small trial
doesn't convince the sceptics." You know, it's the old thing of simply
*stating* someone's position without giving any of the reasons for that
position. It's the intellectually lazy way
of pretending to cover both sides of a story.
The
full answer is in Randi's email session for Horizon, when he replies to
a question about homeopathy in animals thus: "The problem with those
experiments has always been that human beings make the decisions on
whether or not the animals have benefitted from the treatment. If we
were to see experiments done with animals in a double-blind fashion,
and those proved to
be positive, I would accept them as evidence of homeopathy's efficacy."
I get the distinct feeling that the journalist was impressed by the
homeopathic vet's answer and didn't think to check it with any of the
numerous scientists he collected for the story. I accept that the
journo would have had serious time pressures, but still...
But
I have to say that most of my dire predictions did not come to pass.
The journalist gave a fair and accurate description of homeopathy
and the scientific opposition to it; he talked to Benveniste and Reilly
and Ennis (pro-homeopathy scientists); he talked to Randi and Robert
Park and Maddox (homeopathy skeptics) as well as talking to practising
homeopaths. So I think he did a very good job. In full context, this is
a minor slip-up, but I guess it's one of my bugbear subjects, plus I
think it could have been fixed with very little work from the
journalist. So, all in all, I give the report an A-, and I'm a pretty
hard marker.
Peter Macinnis
commented:
You are all
wrong. Homeopathic stuff is better than pure stuff. All
homeopaths know this.
It is the reason
why they are all beating a path to my door to purchase my patented
homeopathic gold (aka seawater) from me. Of course, being a
philanthropist, I make this available in kilogram jars at just half the
price for a kilo of gold.
So long as there
is a crowd of clamouring, money-flourishing homeopaths at my door, and
a trail of jar-clutching homeopaths trekking away from my
door, you anti-homeopath bigots have no leg to stand on.
Podargus
responded:
The
problem as I see it in these sorts of programs, made as they are for
Joe/sephine Average is that the audience is not trained or capable of
appreciating what is required to evaluate the results. So even in
a well made program they will be left with the impression that it
'works'. Someone saying it 'does' is stronger than someone
suggesting that it probably doesn't.
Yesterday
the 'Old Codger' who camps on my place (in a caravan) got all enthused
about the A1 and A2 casein program on 4 Corners. Well he was all
enthused about the A2 and at least in the short term will be
imbibing. He had come away without the concept that there was
some contention in the matter; and he has spent his working life on the
fringes of science. At least it will not be as bad (for me) as
his dabbling into lavender.
Peter Macinnis
replied:
>
I'll be down for the show. I'll order a truck load, providing you
can prove
> it is better than the Byron Bay stuff. Thinks- maybe Unique
Water has a
> better profit margin. Or Byron's own Empowered Water.
You can trust
me, I'm a homeopath. Look, I don't need to prove it: the results
speak for themselves. No, I don't want scientists involved, I don't
want a Nobel Prize or anything. But even scientists will tell you
that my seawater contains homeopathic levels of gold, so what are you
waiting for?
Just send money.
Lots of it.
I also have a
Maxwell's demon box that extracts gold from seawater in large amounts
for those who do not believe in homeopathy. You need to believe in
demons though, which is why you need to pay me $185,000 for it, so I
know that you will believe in anything. Burglars will not steal
it, because it looks just like a matchbox, but I have to warn you that
any flicker of disbelief, and the demons will decamp -- and if you have
made them leave, there can be no refund.
Chris Lawson replied:
>You
can trust me, I'm a homeopath. Look, I don't need to prove it:
>the results speak for themselves. No, I don't want scientists
>involved, I don't want a Nobel Prize or anything. But even
scientists
>will tell you that my seawater contains homeopathic levels of gold,
so
>what are you waiting for?
This
is an outrage and a lie! Since the seawater you are selling has
detectable quantities of gold, it is unfair to call this "homeopathic".
Zero Sum wrote:
<DEVIL'S ADVOCATE MODE>
You know, on
wnders about the morality of people who will destroy the value of a
treatment out of their own sense of certainty and authority.
We all
understand and accept that homeopathic treatments have no technological
basis and that the only merit in them is from the placebo effect.
Given that the
placebo effect may save someone's life, are you justified in saying to
someone whose life might be saved that it is a load of hogwash and
won't help (thereby destroying the placebo effect and killing them?
It is annoying
when the desire to be right exceeds the desire to care for the patient.
The placebo
effect is a subtle and powerful thing.
I suggest to you
as a provocation that the doctor who tells his patient to disregard
homeopathy because there is only the placebo effect has considerably
worse ethics than a knowingly fradulent homeopath, as he has just
tossed away a practical treatment based on the doctors "outrage" not
what might benefit the patient.
How do you feel
about the large number of doctors practising acupuncture?
</DEVIL'S
ADVOCATE MODE>
Peter
Macinnis replied:
At
13:52 3/04/03 +1000, Zero wrote:
><DEVIL'S ADVOCATE MODE>
>
>Given that the placebo effect may save someone's life, are you
justified in
>saying to someone whose life might be saved that it is a load of
hogwash
>and won't help (thereby destroying the placebo effect and killing
them?
></DEVIL'S ADVOCATE MODE>
Just
responding to that bit (I am working tonight, quite by chance, on a
series of vignettes of homeopathic doctors who murdered by poison
[Crippen, de la Pommerais, and Henry Meyer, if he existed], so I am
busy) but I will come in on the side of the angels.
You
may recall the mumblepath who surfaced here last year, whom I
crash-tackled with a question about metastasis from melanoma -- she
replied airily that it was a surface cancer, so metastasis would be no
problem. Wrong answer. It wasn't an unfair test -- she could have
looked it up, but she did not. They never do.
THAT
is why you have to crash-tackle them every time. Because they
will tell people not to allow the doctors to poison them, to take some
magic water, and the cancer will go away.
Well,
perhaps it will, but it will take the patient with it, nine times out
of ten. EVERY homeopath will, sooner or later, murder somebody,
and live the rest of his or her life as a charlatan, a crook, a
fraudster.
peter,
extremely annoyed at the wrap-up.
Zero Sum
responded:
<DEVIL'S
ADVOCATE>
On
Thu, 3 Apr 2003 20:40, Peter Macinnis wrote:
> THAT is why you have to crash-tackle them every time.
Because they will
> tell people not to allow the doctors to poison them, to take some
magic
> water, and the cancer will go away.
>
> Well, perhaps it will, but it will take the patient with it, nine
times
> out of ten. EVERY homeopath will, sooner or later, murder
somebody, and
> live the rest of his or her life as a charlatan, a crook, a
fraudster.
Now you know
that I do not disagree with you, but I have to ask if there have been
any studies of the size of the effects?
Is there any
study to show that any benefits gained from the placebo effect is
outweighed by the effects of 'bad advice'? You seem to be taking
that as a given, but it seems to me that in todays moral climate you
would have to ask "how many lives saved" versus "how many lives lost"
and "how much suffering ameliorated" compared to "how much suffering
increased". Now, I know we are capable of such studies, but have
in fact any been done?
If the answer is
"no", then we are in a situation where we simply do not know which is
the worse evil.
We do know that
the "bad advice" could be remedied with the correct education. I
suggest that when homeopathy was prescribed by doctor's rather than
'wanabees' there would have been far less 'bad advice'.
Looking at it
that way, it might have remained a useful tool in a doctor's arsenal
rather than a disgarded sharp impliment that has been picked up and
used dangerously by quacks.
</DEVIL'S
ADVOCATE>
Chris
Lawson replied:
At
13:52 3/04/03 +1000, Zero Sum wrote:
><DEVIL'S
ADVOCATE MODE>
></DEVIL'S
ADVOCATE MODE>
Understood.
Here
are my responses:
1.
Prescribing something that you know has no effect but placebo is
dishonest. It involves lying to your patient. This is very dubious
ethically.
2.
There are plenty of treatments available which we know work; these will
also have a placebo effect without lying.
3.
When there are no treatments that are proven to work, there are still
treatments with some theoretical justification behind them. The placebo
effect will also apply here, again without lying to the patient.
4.
Even if there are no proven treatments, and no treatments with strong
theoretical claims, there are always modalities such as meditation and
yoga which do not pretend to be curative, but which may help the person
deal with the emotional issues of their problem. These will also have a
placebo effect.
5.
If you recommend the continued use of treatments which are known to be
ineffective, then why test for effectiveness? The only purpose in
scientific testing is to discern whether a treatment is effective; if
you don't adopt effective treatments and abandon ineffective
treatments, then why bother at all?
6.
The placebo effect is greatly misunderstood. It doesn't just apply to
physiological changes due to one's awareness, it also applies to
scientists interpreting their results. Thus it is quite possible for a *harmful*treatment
to be enthusiastically recommended because the placebo effect hides its
harm from researchers and therapists.
7.
The use of placebos discourages people from getting real treatment that
works. Homeopathic vaccines are a good example: there is not a shred of
evidence that they work, yet there are people who use them *instead
of* tested
vaccines that we know work. NSW recently had the case of a naturopath
being convicted of manslaughter for telling parents he could cure their
daughter's heart anomaly -- the child died after the parents cancelled
her surgery.
8.
The desire to be right and the desire to care for the patient are not
contradictory. The whole purpose of modern medical research is to align
these two goals. To knowingly give ineffective treatment and hope for a
placebo miracle is not caring for the patient. It's a combination of
lying and wishful thinking. To tell a patient the treatment they have
been given won't work *is*caring
for patient if you have very good reasons for your position (as is the
case with homeopathy). Telling them the truth may save them from
wasting money (some alternative practitioners charge thousands of
dollars to pensioners), may save them from dangerous advice (see
Peter's comments re: homeopaths and melanoma), may get them to avoid
side-effects for no benefit (not such a problem with homeopathy, but a
big problem with some other alternative modalities) and may get them to
undertake tested treatments earlier than they would otherwise (see the
naturopath manslaughter story above).
8a.
Let me put this another way. I am about to use an example that occurs
not infrequently. Suppose you are a doctor. You see a patient with a
urinary infection and prescribe an antibiotic. You tell the patient
that the antibiotic will probably have a noticeable effect within 24
hours, and has a better than 90% chance of working. This is truthful.
But the next day the patient comes back complaining that the pain is no
better. You check the culture result. The bacterium is resistant to the
antibiotic
prescribed.
Now, in this situation, my strategy would be to express sympathy that
the bug turned out to be resistant to the antibiotic and to prescribe a
different antibiotic according to the bug's sensitivities which are now
known. Your devil's advocate would take a different approach, it seems.
Your advocate seems to be saying that the correct response would be to
say "don't worry about the pain; the antibiotic I gave you is a wonder
drug; keep taking it and you'll feel good as gold in no time at all."
9.
If you really think a deliberate fraud who exploits the fears of sick
people has better ethics than a doctor who tells his patients the
truth, then I guess this has gone beyond Devil's advocacy and into
being confrontational for the sake of confrontation.
10.
Your advocate seems a little confused here. He says that a doctor who
tells a the truth about homeopathy is doing so to assuage his own sense
of outrage. But let's remind ourselves of why the doctor is outraged.
He is outraged because the patient has a pathological condition which
is being "treated" by a practitioner who has no understanding of
physiology or pathology, and who obviously has no understanding of
basic chemistry, and who is telling the patient falsehoods. Or he is
outraged (as I often am) by an alternative practitioner quite simply
*inventing* a pathology to justify bogus treatment. The number of
people I have seen who swear that they have "candida in the blood"
because their naturopath said so is mindboggling. The number of people
I see who "need" to know their blood group so they can follow the blood
group diet is also astonishing. (Almost all of these
people
decide they don't really need the blood test after all when I explain
(i)
the blood group diet is bogus, and
(ii) since there is no medical justification for it, any blood group
testing will be billed privately and not to Medicare. )
To
say that the doctor is telling the truth because he is outraged is the
wrong way round. The doctor is outraged because of the truth he has to
tell.
11.
I am not deeply convinced, but there are sufficient papers showing the
effectiveness of acupuncture for pain relief that I find it quite
acceptable that doctors practise acupuncture. I have even recommended
acupuncture (and not just with acupuncturists medically-trained) for
people with chronic pain.
12.
The advocate says the placebo effect is a subtle and powerful thing.
Find me someone who disagrees. The advocate seems to be labouring
under the misunderstanding that the placebo effect and real physical
effects are mutually exclusive.
and:
>Is
there any study to show that any benefits gained from the placebo effect
>is outweighed by the effects of 'bad advice'? You seem to be
taking that
>as a given, but it seems to me that in todays moral climate you
would have
>to ask "how many lives saved" versus "how many lives lost" and "how
much
>suffering ameliorated" compared to "how much suffering
increased". Now, I
>know we are capable of such studies, but have in fact any been done?
Ummm.
I think you misunderstand how difficult it is to answer the question
the way you want it answered. Just think for a moment about the study
design you would need to decide whether the placebo effect's benefits
outweigh
the risk of bad advice.
>If
the answer is "no", then we are in a situation where we simply do not
>know which is the worse evil.
You
can still draw strong conclusions in the absence of absolute "yes"/"no"
answers. There are many scientific conundra that cannot be solved
simply by doing a definitive study.
>We
do know that the "bad advice" could be remedied with the correct
>education. I suggest that when homeopathy was prescribed by
doctor's
>rather than 'wanabees' there would have been far less 'bad advice'.
>
>Looking at it that way, it might have remained a useful tool in a
doctor's
>arsenal rather than a disgarded sharp impliment that has been
picked up
>and used dangerously by quacks.
This
may be true, but I'm a little curious about the ethics here. You seem
to be suggesting that it might be a good idea for doctors to practise
modalities that they know to be false in order to prevent people from
receiving bad advice from non-medical people using the same modalities.
This seems a bit like destroying the village in order to save it, at
least to me. It also ignores the fact that many people's faith in
homeopathy and other "natural" modalities would only be strengthened by
this strategy. The homeopaths would say, and with complete
justification, "how dare they argue against my advice when they
practise it themselves?"
Ray wrote:
There are those
for whom prognosis is so poor that the last recourse becomes the power
of prayer. (a cover story in Time magazine last decade suggests
some statistical evidence for the effectiveness of prayer -possibly on
as equally shaky grounds as homeopathic results?)
Point is, when
all modern medicine falls in a heap of ineffectuality, which it does
from time to time, what else is left other than opiate assisted
terminal departure, or alternative techniques which have no visible
means of support (or both)?
No MD or medical
scientist would dare to claim they hold the answers to all human ills.
Zero
Sum replied to Chris:
On
Thu, 3 Apr 2003 23:36, Chris Lawson wrote:
> >Looking at it that way, it
might have remained a useful tool in a
> > doctor's arsenal rather than a disgarded sharp impliment that
has been
> > picked up and used dangerously by quacks.
>
> This may be true, but I'm a little curious about the ethics here.
You
> seem to be suggesting that it might be a good idea for doctors to
> practise modalities that they know to be false....
If
a "modality" is known to produce positive results, how can it be said
to be a "false" modality?
Are
hypnotherapy and psychotherapy "false modalities" in the same way?
What
is the difference?
>
...in order to prevent
> people from receiving bad advice from non-medical people using the
same
> modalities. This seems a bit like destroying the village in order
to
> save it, at least to me....
Not
quite what I said. If it remained under the purview of medicine
and not quackery then it would not be legal for the quacks to use it,
and doctors might use it with 'profit' to the patient.
>
It also ignores the fact that many people's
> faith in homeopathy and other "natural" modalities would only be
> strengthened by this strategy...
Half
the people I know think an of an electron as a pea. That does not
stop them using electricity and electronics. Very few people have
an understanding of why they take particular medicines. That even
applies to some doctors (that is not a shot at doctors, you can't keep
up with everything). If the faith in homeopathy led to saving
their lives with a placebo, what right does someone have to interfere
from indignation?
The
only justification is saving lives. If the attitude expends them
it is unsound.
>
...The homeopaths would say, and with
> complete justification, "how dare they argue against my advice
when they
> practise it themselves?"
If
it were under the purview of medecine there would be no medically
unqualified homeopaths. End of problem...
I
still do not see how in good concience an effective treatment can be
dicarded because it is based on false premises.
Ray wrote:
>>I still do
not see how in good concience an effective treatment can be dicarded
because it is based on false premises.
The hazard, I
think, is the dependance on an unlikely cure when simple surgical
excise would be safer.
(back to the
notorious melanoma)
Personally, I
like preop medication. :)
Zero
Sum, responding to Chris' post:
<DEVIL'S
ADVOCATE>
On
Thu, 3 Apr 2003 23:27, Chris Lawson wrote:
>
Here are my responses:
>
> 1. Prescribing something that you know has no effect but placebo is
> dishonest. It involves lying to your patient. This is very dubious
> ethically.
>
Less
so than letting them die for lack of another (or better) treatment?
If
lying might save their life and telling the truth allow them to die?
There
is no time for psychological rebuilding and retraining that may give
them volountary control of the placebo effect.
If
the mind can affect health in such a way, where is the research on how
to train someone to be able to manage this themselves?
>
2. There are plenty of treatments available which we know work; these
> will also have a placebo effect without lying.
>
Adding
"another" placebo could increase the effectiveness of the overall
treatment. How many studies have been done on this? It
might be that a "complex" treatment has benefits over a "simple" one
purely from the placebo effect.
People
always seem to take more joy in a rack of medicines rather than a
single one.
>
3. When there are no treatments that are proven to work, there are still
> treatments with some theoretical justification behind them. The
placebo
> effect will also apply here, again without lying to the patient.
>
Isn't
that the difference between a sin of ommission and a sin of commission?
The
trouble is that saying to a patient that this "may help you but it is
unlikely" might even have a reverse placebo effect.
The
real question here is whether it is possible to give the best treatment
to a patient and still tell them the truth.
>
4. Even if there are no proven treatments, and no treatments with strong
> theoretical claims, there are always modalities such as meditation
and
> yoga which do not pretend to be curative, but which may help the
person
> deal with the emotional issues of their problem. These will also
have a
> placebo effect.
>
Undetermined
by the medical view that these things have no curative value.
Being
told, "Look, mate, you are dying but if you go and do some yoga, you
might be better off. It won't really help, but it might make you
feel better" would seem designed to *counter* the placebo effect.
>
5. If you recommend the continued use of treatments which are known to
> be ineffective, then why test for effectiveness? The only purpose
in
> scientific testing is to discern whether a treatment is effective;
if
> you don't adopt effective treatments and abandon ineffective
treatments,
> then why bother at all?
>
The
argument here is that it is not proven to be effective or ineffective.
We know there are some wins and some losses, but we have not
quantasised that so no claims of relative effectivity can be made.
We
need to distinguish when we are talking homeopathy and when we are
talking placebo. Homeopathy does not work, placebo does.
>
6. The placebo effect is greatly misunderstood. It doesn't just apply to
> physiological changes due to one's awareness, it also applies to
> scientists interpreting their results. Thus it is quite possible
for a
> *harmful* treatment to be enthusiastically recommended because the
> placebo effect hides its harm from researchers and therapists.
>
Perhaps
what is needed is more research into the placebo effect, how it works
and how to make it more effective.
Was
there not some study that showed that having people praying for you had
a practical effect even if the patients did not know they were being
prayed for and the people making the prayers did not know the identity
of the patient?
If
a combined treatment of "harmful" plus "placebo" has a beneficial
effect,
can the overall (combined treatment) be said to be "harmful" - No,
I
don't think so. It could be said that the effectiveness would be
increased
if you could replace the "harmful" part, but the overall
tereatment
could not be called "harmful" (given that in the majority of
cases
a benefit results).
>
7. The use of placebos discourages people from getting real treatment
> that works. Homeopathic vaccines are a good example: there is not a
> shred of evidence that they work, yet there are people who use them
> *instead of* tested vaccines that we know work. NSW recently had
the
> case of a naturopath being convicted of manslaughter for telling
parents
> he could cure their daughter's heart anomaly -- the child died
after the
> parents cancelled her surgery.
>
Cognitive
dissonance.
Hang
on we do know that the placebo effect does
work. How can it be an "ineffective" treatment? There is a
difference between something being "ineffective" and "misapplied".
I
am not aguing a case for the effectiveness of homeopathy.
>
8. The desire to be right and the desire to care for the patient are not
> contradictory. The whole purpose of modern medical research is to
align
> these two goals...
I'm
_not_ sold on that. The desire to be right should be of no
relevance whatsoever.
>
To knowingly give ineffective treatment and hope for a
> placebo miracle is not caring for the patient. It's a combination
of
> lying and wishful thinking. To tell a patient the treatment they
have
> been given won't work *is* caring for patient if you have very good
> reasons for your position (as is the case with homeopathy).
Caring
for the patient is providing for optimum chances of survival. if
that includes lying then that is providing the optimum care. I
have been knowingly lied to by doctors before and have found many that
are very willing to lie to their patients - even lying about what they
have observed.
Example:
In 1984 a doctor told me that I should give up smoking because I had
emphysema (a knowingly told lie). Now, if he had said "would get"
rather than "got" he might not have disembowled the credibility of his
profession. He knowingly lied in an attempt to improve my
health. What is the difference here?
>
...Telling them
> the truth may save them from wasting money (some alternative
> practitioners charge thousands of dollars to pensioners), may save
them
> from dangerous advice (see Peter's comments re: homeopaths and
> melanoma), may get them to avoid side-effects for no benefit (not
such a
> problem with homeopathy, but a big problem with some other
alternative
> modalities) and may get them to undertake tested treatments
earlier than
> they would otherwise (see the naturopath manslaughter story above).
>
All
of these points are based on the current situation where homeopathy
(and it's ilk) are not under medical purview. They would not
apply so readily had homeopathy (and it's ilk) remained under medical
purview.
>
8a. Let me put this another way. I am about to use an example that
> occurs not infrequently. Suppose you are a doctor. You see a
patient
> with a urinary infection and prescribe an antibiotic. You tell the
> patient that the antibiotic will probably have a noticeable effect
> within 24 hours, and has a better than 90% chance of working. This
is
> truthful. But the next day the patient comes back complaining that
the
> pain is no better. You check the culture result. The bacterium is
> resistant to the antibiotic prescribed. Now, in this situation, my
> strategy would be to express sympathy that the bug turned out to be
> resistant to the antibiotic and to prescribe a different antibiotic
> according to the bug's sensitivities which are now known. Your
devil's
> advocate would take a different approach, it seems. Your advocate
seems
> to be saying that the correct response would be to say "don't worry
> about the pain; the antibiotic I gave you is a wonder drug; keep
taking
> it and you'll feel good as gold in no time at all."
>
No,
I don't think I have said, or suggested anything like that at all. In
fact I think that is a rather absurd twist on what I have said.
>
9. If you really think a deliberate fraud who exploits the fears of sick
> people has better ethics than a doctor who tells his patients the
truth,
> then I guess this has gone beyond Devil's advocacy and into being
> confrontational for the sake of confrontation.
>
No,
no. But are you not "case building" here? "deliberate
fraud", "exploits the fears...". You are making out the worst
possible case and in such cases, extreme action to prevent
repetition is more than acceptable (In other words, "hang 'em
high"). But these are not the majority of the cases.
All
I have done is question the ethics of abandoning a treatment that can
be effective (via the placebo effect). I have further questioned
the ethics of releasing that treatment (homeopathy) into the public
domain (rather than the purview of medecine) where it can and does do
considerable harm.
There
were/are a number of other options.
You
can justifiably accuse me of being confrontational, but not with
hostility. I am confronting a paradox in viewpoints and asking
for it to be explained (justified?). I figure that if we do
reconcile this, then we have improved the situation for all.
("reconsile" does not mean accepting homeopathy as a valid treatment in
its own right).
>
10. Your advocate seems a little confused here. He says that a doctor
> who tells a the truth about homeopathy is doing so to assuage his
own
> sense of outrage. But let's remind ourselves of why the doctor is
> outraged. He is outraged because the patient has a pathological
> condition which is being "treated" by a practitioner who has no
> understanding of physiology or pathology, and who obviously has no
> understanding of basic chemistry, and who is telling the patient
> falsehoods. Or he is outraged (as I often am) by an alternative
> practitioner quite simply *inventing* a pathology to justify bogus
> treatment.
<snip>
I
think we are both a little confused. I agree with everything you
say here, but it still does not help me understand how ethicly a
treatment that has been shown to be effective (the placebo effect) can
be disgarded and ignored when lives are at stake.
I
am suggesting that an efective and ethical way of using this has to be
found. it is too important and too powerful to be ignored or
disgarded.
>
11. I am not deeply convinced, but there are sufficient papers showing
> the effectiveness of acupuncture for pain relief that I find it
quite
> acceptable that doctors practise acupuncture. I have even
recommended
> acupuncture (and not just with acupuncturists medically-trained)
for
> people with chronic pain.
>
I
have had accupuncture from medically trained people and chinese trained
accupunturists. There is no comparison between the two. It
is the skills of the accupuncturist him/herself that is important not
the needles or precision in locating (in my opinion fictional)
"points". It can't be learned from a book. (But this is for
a seperate thread).
>
12. The advocate says the placebo effect is a subtle and powerful thing.
> Find me someone who disagrees. The advocate seems to be labouring
under
> the misunderstanding that the placebo effect and real physical
effects
> are mutually exclusive.
>
The
advocate does not think so. The advocate is not looking to
replace current treatments but to suppliment them.
You
say that you disagree that "the placebo effect is a subtle and powerful
thing". That seems to fly in the face of modern medicine.
</DEVIL'S
ADVOCATE>
Peter Macinnis
replied:
>
If it were under the purview of medecine there would be no medically
> unqualified homeopaths. End of problem...
If they were
qualified, they wouldn't be homeopaths!
Dr. Crippen was
a homeopath, and when that did not pay enough, he tried being a
dentist, using his homeopathy training. It paid well -- which
makes one wonder about the qualifications of dentists in those days.
I draw no
inference from that about homeopathy, but I will from this:
Couty de la
Pommerais might have got away with murder if he had not been a
homeopath. You see, he had this big jar, almost empty, originally full
of a poison that could have been the one that killed his former (and
wildly over-insured) mistress. And people said that no homeopath
could have used it all in his practice. Snick!
Boys and girls,
don't be homeopaths when you grow up -- it increases your chance of
being guillotined!
Paul Williams wrote:
>
There are those for whom prognosis is so poor that the last recourse
becomes
> the power of prayer. (a cover story in Time magazine last
decade suggests
> some statistical evidence for the effectiveness of prayer
-possibly on as
> equally shaky grounds as homeopathic results?)
>
All the studies
I've read regarding the effectiveness of prayer have either shown no
difference to survival times or were considered to be flawed.
There may be other 'positive' studies but I'm unaware of them.
>
Point is, when all modern medicine falls in a heap of ineffectuality,
which
> it does from time to time, what else is left other than opiate
assisted
> terminal departure, or alternative techniques which have no
visible means of
> support (or both)?
>
Preying on the
weakened and desperate appears to be the modus operandi of delusional
would be messiahs and those whose god is mammon. These creatures have
no place in a caring world. The morality of assisted death should
perhaps be judged by those horribly dying. It is not caring to
offer false hope. Positive attitudes are essential, but there
comes a time when there is
no tail end to
the graph of survival to rely on anymore.
>
No MD or medical scientist would dare to claim they hold the answers to
all
> human ills.
Indeed.
- Some alternative creatures do though.
Chris Lawson
posted:
At 09:41 4/04/03
+1000, Zero Sum wrote:
>If
a "modality" is known to produce positive results, how can it be said to
>be a "false" modality?
If a modality
only shows placebo benefit, then it is the placebo causing the benefit,
not the modality, and it is perfectly reasonable to call it a false
modality.
>Are
hypnotherapy and psychotherapy "false modalities" in the same way?
>What is the difference?
There are
well-conducted studies into the effectiveness of both hypnotherapy and
psychotherapy that show that both modalities have the capacity to
improve some conditions. This does not mean that *all*forms of
psychotherapy are effective, and not for all conditions. I would also
point out that I have grave concerns about some forms of these
therapies -- I said so in a recent blog entry. See my 3 March entry,
"The scientist-therapist gap", or link to:
http://members.ozemail.com.au/~claw/frankenarchive007.htm#20030303-01
>Not
quite what I said. If it remained under the purview of medicine
and
>not quackery then it would not be legal for the quacks to use it,
and
>doctors might use it with 'profit' to the patient.
I think you'd
find it hard to introduce legislation banning non-doctors from
recommending homeopathy while allowing doctors, most of whom don't
believe in it, access. I don't think you can justify this on either
ethical or practical grounds.
>
> It also ignores the fact that many people's
> > faith in homeopathy and other "natural" modalities would only
be
> > strengthened by this strategy...
>
>Half
the people I know think an of an electron as a pea. That does not
>stop them using electricity and electronics. Very few people
have an
>understanding of why they take particular medicines. That
even applies to
>some doctors (that is not a shot at doctors, you can't keep up with
>everything). If the faith in homeopathy led to saving their
lives with a
>placebo, what right does someone have to interfere from indignation?
I already
answered that.
>The
only justification is saving lives. If the attitude expends them
it is
>unsound.
Show me a single
trial showing that homeopathy has saved lives. In over 200 trials, the
most effective result has been in the treatment of hay fever. And even
this trial is, IMHO, not particularly well-researched (although they
did do a good randomisation). The other trials have shown homeopathy
doesn't work or at best has a borderline effect when giving maximal
statistical
massage. This is a spurious argument.
>
> ...The homeopaths would say, and with
> > complete justification, "how dare they argue against my
advice when they
> > practise it themselves?"
>
>If it were under the purview of medecine there would be no medically
>unqualified homeopaths. End of problem...
See above. This
is not a realistic option.
>I
still do not see how in good concience an effective treatment can be
>dicarded because it is based on false premises.
I answered this
in my other post. To summarise: if you know the only benefit of a
therapy is placebo, then to use that therapy involves lying to your
patients; there are other modalities which are not known to be false
and these will also elicit an effective placebo response; there are
dangers associated with relying on placebo effect, including that
patients avoid or delay treatments that are known to work.
and:
At 10:43 4/04/03
+1000, Zero Sum wrote:
>
> 12. The advocate says the placebo effect is a subtle and powerful
thing.
> > Find me someone who disagrees. The advocate seems to be
labouring under
> > the misunderstanding that the placebo effect and real
physical effects
> > are mutually exclusive.
>You say that you disagree that "the placebo effect is a subtle and
powerful
>thing". That seems to fly in the face of modern medecine.
Geoff, I was
thinking of replying to this post in detail, but I don't see the point.
You're arguing in circles and you're not seeing what I'm saying. Try
reading what I said above (ie, that everyone agrees placebo effect is
powerful and subtle) and how you interpreted it (the exact opposite).
If this were just one line, I'd not mention the matter, but since this
permeates everything in the post, and given the context of about a
dozen times I've said there are better ways of getting a positive
placebo effect, the fact that you could come to this conclusion means
you're not actually responding the things I'm saying but to the things
you think I'm saying.
Donald
Lang wrote:
I
did not get to watch the program last night. I had to record it while
dedicated watchers were busy with real medicine on "Scrubs".
I
have now watched it, and am wondering if there is any water anywhere
that has C30 status for any chemical substance. In case anyone is
interested and did not watch, homeopaths like to dilute their
substances by a factor of a hundred, thirty times. [presumably C for
hundredfold dilution, and thirty is efinitely the claimed number of
times.] I am not going to seek out a
homeopath
to ask, but anyone who has an encounter of a C30 kind might like to ask
how you know which medicine you are using.
<IN
MEMORY OF FRED HOYLE>
Since
C30 dilution of one ml of any substance requires more water than is
available on the entire planet, and even a lot further afield, perhaps
the *real* medicine is introduced in this step and comes from
outer space.
</IN
MEMORY OF FRED HOYLE>
The
point Chris made earlier about checking on the working of placebos was
actually visible in the first program. People who "knew" which samples
were "medicines" saw those samples as working. At least that was the
message I got. Once they were in fact double blind the effect went away.
Zero Sum replied:
On Fri, 4 Apr
2003 21:03, Chris Lawson wrote:
>
At 09:41 4/04/03 +1000, Zero Sum wrote:
> >If a "modality" is known to produce positive results, how can
it be
> > said to be a "false" modality?
>
> If a modality only shows placebo benefit, then it is the placebo
causing
> the benefit, not the modality, and it is perfectly reasonable to
call it
> a false modality.
>
Okay.
False, but not ineffective. The nature of a placebo is that is
hidden. Or is it? Have any studies been done on the placebo
effect when a portion of the subjects are knowingly taking a placebo?
The answer to
this is critical to my reasoning and I have just realised I was
assuming the answer...
[snip]
>
> >Not quite what I said. If it remained under the purview
of medicine
> > and not quackery then it would not be legal for the quacks to
use it,
> > and doctors might use it with 'profit' to the patient.
>
> I think you'd find it hard to introduce legislation banning
non-doctors
> from recommending homeopathy while allowing doctors, most of whom
don't
> believe in it, access. I don't think you can justify this on either
> ethical or practical grounds.
>
There was a time
when people who were not medicly qualified could not practise
homeopathy because it was regarded as medecine. What I am trying
to say is that it would be better if that still were the case.
Quacks could not use it. Let it fall out of use as "bad" medecine
and leave open the option of a doctor using it as a placebo.
"Bleeding"
people (phleg...?) is not practised as medicine anymore except in rare
and emergency cases (IIRC) but it hasn't been "released" to quacks to
practise.
I think that for
me, homeopathy seems a bit like a discarded surgical instument left
around for children to play with.
The ethics of
using a placebo whether or not is homeopathy is a separate argument
that we go ito below.
[snip]
>
> >The only justification is saving lives. If the attitude
expends them
> > it is unsound.
>
> Show me a single trial showing that homeopathy has saved lives. In
over
> 200 trials, the most effective result has been in the treatment of
hay
> fever. And even this trial is, IMHO, not particularly
well-researched
> (although they did do a good randomisation). The other trials have
shown
> homeopathy doesn't work or at best has a borderline effect when
giving
> maximal statistical massage. This is a spurious argument.
>
It isn't
homeopathy that I would support even in Devil's advocate mode, but eh
use of it (as an ineffective method) to effectively muster a placebo
effect.
> > > ...The homeopaths would
say, and with
> > > complete justification, "how dare they argue against my
advice when
> > > they practise it themselves?"
> >
> >If it were under the purview of medecine there would be no
medically
> >unqualified homeopaths. End of problem...
>
> See above. This is not a realistic option.
>
I don't believe
this. The issue is how we achieve it. It may be realisticly
unachievable but we haven't even considered any methods by which such a
goal might be achived so I am not willing to reject it out of hand.
> >I still do not see how in good
concience an effective treatment can be
> >dicarded because it is based on false premises.
>
> I answered this in my other post. To summarise: if you know the
only
> benefit of a therapy is placebo, then to use that therapy involves
lying
> to your patients; there are other modalities which are not known
to be
> false and these will also elicit an effective placebo response;
there
> are dangers associated with relying on placebo effect, including
that
> patients avoid or delay treatments that are known to work.
>
Understood.
But my aim here (if I have one) is to try and formulate a means by
which a valid method (the placebo effect) can be used to save
lives. We know that it is a valid effect, that it can save
lives. To ignore it because it means lying to your patient, well
is the patients death the lesser evil?
But this (my
original idea) has become moot because I do not know if the placebo
effect will work with all or a portion of suceptible patients when they
knowingly take the placebo.
Toby
Fiander wrote:
Just
a note on bleeding people....
I
understand that there are several blood disorders for which "bleeding"
is the treatment of choice. Haemochromatosis is the principal
example. So as not to alarm the populace, it is sometimes called
phlebotomy or venesection.
.Nisaba
may be able to speak glowingly of the return of leeches... for removal
of blood from bruised and even transplanted digits.
AFAIK,
eye of newt has not yet re-appeared in the medical repertoire.
Paul Williams
responded:
<snip>
> Have any studies been done on the placebo effect when
> a portion of the subjects are knowingly taking a placebo?
>
<snip>
> But this (my original idea) has become moot because I do not know
if
the
> placebo effect will work with all or a portion of suceptible
patients
when
> they knowingly take the placebo.
I've been
thinking about this in particular, as I'm certain that I've read of a
trial where a study group were told they were taking placebos. Even
with this knowledge, a placebo effect was still measurable. The
thought was that they felt important for being involved in a trial.
Self-esteem boost in itself would appear to have a positive effect.
Annoyingly, I cannot now find this study listed anywhere.
This is merely a
proposal for a study:
"He proposes
that researchers design trials in which half the participants are told
they are getting a placebo and half are told
they're
receiving the active treatment. Yet each of the two halves of the study
would be split again, so half of each group would get the active drug
and half the placebo. Thus, some people would mistakenly believe they
were receiving the placebo when they were actually taking the active
drug, and vice versa."
The above comes
from a very good overview of scientist's viewpoints in regard to
placebos:
http://www.sciencenews.org/20010203/bob9.asp
I'll keep
looking for the study I read about...it may be in PubMed.
The discussion was opened again, on
31/8/2003, when Sandra (A Time for Peace) asked the meaning of the word
"sarcode"....
Ray replied, and Sandra answered:
Thanks Ray, but this is not
the meaning I am looking for. I was looking for a homeopathic remedy to
stimulate the pituitary gland. I noticed that some sites sell
Pituitarum Posterium and others Pituitarum Posterium Sarcode. So I was
wondering if there is a difference, and if so what that difference is.
Anne
responded:
"A
sarcode is a section of healthy tissue used in homeopathic remedies
that is prepared similar to a nosode "
From
http://altmed.creighton.edu/
another
site that i love and others have cited is
http://www.skepdic.com
nothing
on sarcode but much on homeopathy
Ray commented:
Sandra, for
homeopathy just use distilled water.
If you don't
tell the patient, believe me, they won't know the difference.
:)
David
Martin noted:
You
should be more careful with your advice.
In
homeopathy, efficacy is presumed to increase with dilution. Distilled
water is an infinitely diluted form of every known remedy (indeed,
every possible substance) and is very potent material. It should be
prescribed only by a qualified homeopath.
:-)
Paul Williams
added:
This has a deep
'homeopathological' inference, in that imbibing seawater (5 picolitres
perhaps?) would cure every ill known to man. The downside to this would
be that this same dose would actually cause every one of these very
same ills...
Further to the
above, it seems like a very hard thing that people who supply watered
down alcoholic spirits should be prosecuted - and if they were
prosecuted, one feels that this should be for actually causing
drunkeness...
Sandra
replied:
The patient may not know the difference when taking it, but they will
notice the
difference in their health after taking it! How
many homeopathic remedies have you taken in your life. I hope you have not
made this statement without experience, Ray
Ray responded:
Sandra, no I
have no anecdotal evidence to support my facetiousness. It
is just very difficult for any other kind of evidence (than anecdotal)
to prove homeopathy beyond random chance and a placebo effect.
At the same time
however, nothing provided by contemporary medicine has yet (anecdotally
speaking for 5 years, on and off) relieved me of tinnitus or an
annoying fungal infection of an ear canal. I'm currently
attempting to grow a culture of whatever organism it is, and whilst
tempted to use dilute copper sulphate... I think not.
If it works, or
even if you think it works, and as a consequence it does, then good and
well. I would not like my life to hang on the effectiveness of
homeopathy, which of itself might mean that homeopathic treatment has
no chance at all of working for me.
If feeling awry,
I'd be prepared to trust aromatherapy more.
Podargus,
replying to Paul:
> This has a
deep 'homeopathological' inference, in that imbibing seawater
> (5 picolitres perhaps?) would cure every ill known to man.
> Regards
> Paul
The problem with sea water is that
it has detectable amounts of 'stuff', therefore would need diluting to
be effective.
Rob, replying to Peter:
> Please don't hold back -- I would
love to see what a
> homeopath has to say about ignorance.
Out of interest Peter, had you ever wondered about the amount of
research into naturally occurring toxins,
and their application in disease control? Maybe there's some
parallels with the use of diluted toxins in homeopathy? I'm not
saying I agree with homeopathy, but I think science still has a lot to
learn from "alternative medicine".
While there's an awesome amount of knowledge accumulated by science,
there's still a lot which science fails to explain. In some
respects, there are people who are such focussed "believers" in
science, that their belief results in the same sort of blindness to
alternative explanations that other religions do.
Susan
Wright posted:
Hi Sandra (if you're still onlist)
<Sandra wrote
- snip>>>>>
I thought it was too good to be true, that I could successfully
communicate
with scientists.
<snip>
There have been many discussions
of homeopathy, among the hundred of others topics, on this list. How
useful it may be; how rigorous testing is; evidence; facts etc etc.
Lots of digs about it as well ... but that does not
mean scientists are poor
communicators - merely that they value rigour. Homeopathy as a
subject is not immune regardless of how highly it may be valued by
individuals.
This statement also comes from a
non-scientist (just about as non as you can get).
David's remarks are actually
logical (in a tongue in cheek way)- and useful as a prompt for further
discussion. Because they poke fun shouldn't really matter - it's not a
personal attack on anyone. Simply ask more questions
i.e. why do you think that, what
gaps do you see in evidence/testing etc.
Ian Musgrave wrote:
At 03:43 1/09/03 -0700, Rob wrote:
>--- Peter Macinnis <macinnis@OZEMAIL.COM.AU> wrote:
> > Please don't hold back -- I
would love to see what a
> > homeopath has to say about ignorance.
>
>Out of interest Peter, had you ever wondered about the
>amount of research into naturally occurring toxins,
>and their application in disease control?
Peter sure has. For example a synthetic version of a component of the
toxin from the venomous cone shell Conus magus is being used to treat
chronic pain. Some modern anti-hypertensive drugs are based on the
snake venom component saitiotoxin. And there is digitalis, the toxic
component of foxglove, used to treat heart failure.
>Maybe
>there's some parallels with the use of diluted toxins
>in homeopathy?
No. The principles are completely unlike homeopathy (like cures like),
and is ground firmly in modern biology. And of course they are not used
at infinite dilution, but at dilutions where there is actually some
product. As a pharmacologist I have tested the above toxins, and can
confirm that they work according to the law of mass action, not
homeopathic principles. Also they act on on defined
receptors/enzymes not "like cures like". Digitalis inhibits the
sodium-potassium ATPase, the coneshell venom inhibits N-type calcium
channels and saitotoxin and its therapeutic cousins inhibit anigotensin
converting enzyme.
>I'm not saying I agree with
>homeopathy, but I think science still has a lot to
>learn from "alternative medicine".
There is no "alternative medicine" there is only medicine that has been
shown to work, and medicine that has no evidence of efficacy.
Science already knows that many plants have bioactive substances, and
that they are present in wildly differing amounts between plant
preparations, and if they are not stored properly the bioactive
components will go off, and you have to be careful with identification
and processing or your herbal preparations will get contaminated with
undesirable, possibly lethal, substances. Many "alternative"
practitioners still haven't worked this out.
>While there's an awesome amount of
knowledge
>accumulated by science, there's still a lot which
>science fails to explain.
Thank goodness, otherwise there would be nothing left for us
researchers to research.
However, homeopathic "medicine" does not fall into this category.
Rob
Geraghty replied:
> There is no
"alternative medicine" there
> is only medicine that has been shown to
> work, and medicine that has no evidence
> of efficacy.
So no knowledge other than the
result of scientific research has any value? Actually, your
statement above could be applied equally to things which are classed as
"alternative medicine" as well as Medicine (with a capital M for want
of an exhaustive definition).
A lot of useful research has
stemmed from home remedies, herbal treatments and traditional medicines
(in the latter I'm trying to
categorise treatments used by tribal cultures). I'm not at all
convinced that science has already learned all it can from such sources.
> Science
already knows that many plants
> have bioactive substances, and that
> they are present in wildly differing
> amounts between plant preparations,
Just ask Pan Pharmaceuticals. :)
> However,
homeopathic "medicine" does not
> fall into this category.
For the record, I don't think
homeopathic remedies are likely to show much more than a placebo effect.
However, I don't think it's
necessary to make insulting jokes in the presence of people who may
feel otherwise.
David Martin wrote:
First of all, my apologies, Sandra, for what was really a cheap shot; I
hope it hasn't pushed you off the list. My thanks to Sue in particular,
and others, who have given much more measured responses to the topic.
Nevertheless Sandra, if you express a belief in homeopathy then, on a
science list, you should be prepared for a bit of flack.
The process of science is the testing of ideas against measures such as
internal consistency, experimental evidence, well established
scientific laws and so on. This process is, quite deliberately,
rigorous and thorough,
often to the point of appearing hostile. If it wasn't, false ideas
would easily slip through the net and science would founder. The
following quote, I think from Galileo, sums up the enterprise of
science very nicely:
"The aim of science is not to open the door to everlasting wisdom but
to set a limit on everlasting error".
Any perceived hostility is meant to test your ideas and should not be
taken personally. If you can't defend an idea then you can't lay claim
to it. Those of us on the list who are professional scientists are well
used to this process, but it can be a bit of a shock to non-scientists.
Anyway, as Sue has pointed out, the point of my previous email
(neglecting the sarcasm :-) was that a logical consequence of
homeopathy would seem to be that pure water is a potent cure for all
ills. Perhaps you'd like to
comment on that?
Ian
Musgrave posted:
At 05:28 1/09/03 -0700, Rob
wrote:
>--- Ian
Musgrave & Peta O'Donohue <reynella@MIRA.NET>
>wrote:
> > There is no "alternative
medicine" there
> > is only medicine that has been shown to
> > work, and medicine that has no evidence
> > of efficacy.
>
>So no knowledge other than the result of scientific
>research has any value?
No, read that again. When you or I
take a drug, whether it be an aspirin tablet or powdered willow bark,
we want to know if it works, and if it is safe to use. We we are
testing conventional drugs, we don't take anyones sayso as evidence,
there has to be a rigorous testing procedure to ensure the drug does
work as advertised. We have these rigorous testing procedures because
our "common-sense" notions of what constitutes proof that a drug works (Aunty-Flo ate thin sliced
cucumber and her arthritis went away, so thin sliced cucumber is a cure
for arthritis) are usually badly wrong, as we have discovered to our
cost. There is a reason why it takes 15 years and half a billion dollars to bring a
new drug from discovery to clinical use.
Many natural products that are
used as folk remedies do in fact do useful things (after all, our
ancestors weren't fools, and were capable of astute observation). Even more folk remedies do nowt, and many of the
ones that
do work have really horrible side
effects, but this was NOT picked up by our astute ancestors because
testing medicines is HARD, variable disease courses, responder vs
non-responder sub groups, and plain wishful thinking can overcome the
best of us unless we have a VERY rigorous testing procedure. Why do you
think conventional medicine has the double blind controlled trial as
it's golden standard, because we know from bitter
experience how easy it is to be
fooled.
Folk wisdom doesn't work to well
on things that have long lag times also, in Southern China there is a
region which has a staggering incidence of oral cancer. It turns out
the local delicacy, fermented cabbage, was made
with a fungus as the fermenting
agent which produced a extremely virulent carcinogen. Folk wisdom and
observation didn't catch this, despite the locals being astute.
Most folk remedies haven't even
undergone the most basic of testing to see if they actually do
anything, let alone testing for toxic side effects. Those that have,
like powdered willow bark, have generally been tested by poor, reviled
conventional medicine. And conventional medicine picks up the
pieces afterwards. And if you are thinking "these things have
been used for thousands of years, they must be safe or the locals would
have noticed", remember the pickled cabbage. Even persuasive,
consistent side effects can be hard to pick up, unless you have a
rigorous, dare I say it, scientific, testing proceedure.
Generally, "alternative" medicine
lacks even the barest semblance of testing of any sort, let alone
rigorous.
>Actually,
your statement
>above could be applied equally to things which are
>classed as "alternative medicine" as well as Medicine
>(with a capital M for want of an exhaustive
>definition).
Yep, there is this whole field
called evidence-based medicine. The whole point is to make sure every
therapy we use actually works as advertised. Much to the annoyance of
some drug companies.
>A lot of
useful research has stemmed from home
>remedies, herbal treatments and traditional medicines
>(in the latter I'm trying to categorise treatments
>used by tribal cultures). I'm not at all convinced
>that science has already learned all it can from such
>sources.
Sure we can learn more, but be
aware that just as many traditional medicines do nothing as those that
do. And those that work are often based on an active component that we
have already defined and made better variants of (many Chinese
tradition medicine for colds and flu revolve around ephedrine, we use a
variant, pseudoephedrine, which is more selective and effective and a
bit less likely to kill people with high blood pressure.)
> > Science already knows that
many plants
> > have bioactive substances, and that
> > they are present in wildly differing
> > amounts between plant preparations,
>
>Just ask Pan Pharmaceuticals. :)
Exactly, Pan Pharmacetical was
"Natural Products" company, one of the biggest suppliers of
"alternative" medicine in Australia. The powers that be at Pan
evidently didn't think the conventional science idea of testing your drugs to make sure they had what
they said they had in them was worthwhile. How wrong they were.
Sandra replied:
To Peter,
I am still here.
Firstly, I am not a practitioner. I would sincerely hope that I would
know the meaning of sarcode if I were. I am a philosopher, amongst
other things.
Regarding ignorance: I was going to say that one should not comment on
subjects one knows nothing about, let alone give incorrect advice. This
was directed towards Ray, not David. David may have had tongue in cheek
and I will answer David's post later.
A doctor has only cured me of one thing, and that was amoebic
dysentery, which was poisoned. I was poisoned, with arsenic no less.
For all other maladies during my life, I have cured myself by
self-prescribing. I have used many different homeopathic remedies
successfully. I have also used Bach Flower remedies and Bush Flower
essences made by Ian White, whom I have met. I have also used herbs and
even Purple Plates, all with success.
Unlike left-brained scientists, I don't always need to know how
something works. The fact that it does is often enough for me. I am
neither left nor right brained. I use the left hemisphere when I want
to analyse something
and the right hemisphere when I want to be creative. I use the left
when I am being critical and the right when being insightful or
intuitive. I have even taken a test which showed that I have perfect
balance. Out of twenty
questions, I answered 10 with the left hemisphere and 10 with the right.
and:
Ian,
I have written several letters to the NCI of USA and have not received
one reply. All my letters were concerning natural treatments and cures.
I asked them to comment on Hulda Regehr Clark's two books The Cure for
all Diseases and The Cure for all Cancers. I also sent copies of the
letters by fax. When Hulda Clark was arrested and thrown into jail for
advocating that she could cure cancer. I wrote again and asked them if
there was something they could do for her. No reply!
After visiting their Website, I realised that they are not the least
interested in natural cures. If it is not radiation, chemo therapy,
MammoSites and the like or drugs, they don't want to know about it.
This is a very narrow view. How can drugs ever be superior to natural?
If a person has tried every natural therapy and none of them worked,
then drugs etc. should be used as a last resort. Okay, jump up and down
and scream at me, or be sarcastic --whatever, but nothing will convince
me that unnatural is better than natural. Or that synthetic is better
than organic.
The reason scientists have not got the proof they need for homeopathic
remedies is because the persons used in the trials were not highly
evolved (spiritually) enough for it to be of benefit. I believe it to
be quirte true that a lower evolved soul can not benefit from
homeopathic remmedies. Also an overly sceptical person can block the
healing process and this could be transfered from the scientist to the
patient. So with a combination of a less than highly evolved person
being trialed and a highly sceptal scientist, what hope have you got?
A person must have reached a certain level of awareness for
homeopathic remedies to work. Please note that lower class, uneducated
people are not attracted to these types of remedies. They run to the
doctor at the first sign of illness and do NOT take responsibility for
their health!
and:
Well David, I think science flounders, founders
frequently. You only have to look at how many people science has not
cured. How many people die in hospital and how many diseases there is
NO cure for. How many so called
cures have terrible side affects and and the very methods used as
cures. e.g cutting out disease, poisoning parasites and radiating all
else. I don't consider cutting to be a cure, even if the condition does
not return. The
problem I have with doctors is that they see only the disease and want
to supress the symptoms. This is not a cure. The symptoms may
disappear, only to reappear as something else When you go to a
Naturapath. They treat the whole person. ie the whole of the body, the
mind and emotions and the spirit or soul. Most scientists don't even
know what the soul is, and can not identify with it. Am I not correct
here?
When I said that I thought it was too good to be true that I could
successfully communicate with scientists; I did not mean that
scientists were not good communicators. I meant that I probably would
not have the ability to communicate with them.
Steve Van Zed wrote:
I agree whole hardly with you about not
treating the "whole body". Symptoms may disappear and reappear as
something else. Treating symptoms only is not the - total - answer.
Try to tell that to a hard pressed GP who is critisised for
spending too much time per patient!!.
If you find some one, herbalist,
doctor, naturopath, able and willing to listen, stick to that person.
But use common sense, try to - how difficult it may be - identify
quacks.
Personally I don't believe in
dilutions in the order of one thousands of a milliliter or even less,
but I have seen remarkable results of applying some substances. On the
other hand I remember going with my mother to a herbalist who
prescribed some awful tasting herbal drinks. I don't remember any
benefits, but I am sure it made my mother feel good! Sorry I can't be
more supportive, but equally I am convinced that there is so much more
to medicine than just science.
Ian Musgrave responded:
Answering Sandras
answer to David first, I'll have the other email finished
later tonight.
At 01:14 5/09/03 +1000, Sandra
wrote:
>Well David, I
think science flounders, founders frequently. You only have to
>look at how many people science has not cured.
For a proper answer, you have to
express it as a ratio to the people science has cured. As little as 50 years ago high
blood pressure was a death sentence. It is not now, because of a
combination of simple and effective drugs and diet and behavioral
changes discovered by medical sciences. As little as 20 years ago
childhood leukemia was incurable, now the cure rate is around 90%. 5
years ago Chronic Myeloid Leukemia was virtually incurable, with the
advent of the drug Glivec, there is a better than 80% cure rate. TB was
one of the commonest causes of death in my grandfathers generation, now
it is almost unheard of. If you look at childhood death over the last
20 years alone, it has continually fallen due to improved techniques
and improved medicines from science.
Just think of all the things we don't die from now, due to science (tetanus,
whooping cough, strep throat), and the disease that have virtually
vanished from the planet (small pox, rickets) due to science.
>How many
people die in
>hospital
Quite a few, but far fewer than used
to.
>and how many
diseases there is NO cure for.
Quite a few, usually rare diseases
like Neimann Pick disease (which we now have a treatment for, thanks to
scientists at the Royal Adelaide Hospital), gene diseases like
childhood onset diabetes (for which we have effective treatments,
thanks to science), and diseases of poor people, like malaria (and
Australian scientists have been hammering away at malaria for ages,
some preliminary vaccine trails seems hopeful, but Big Pharma isn't
interested in diseases of the poor, this isn't the scientists fault
though, and the WHO may be able to do something in this area)
>How many so
called
>cures have terrible side affects
Very few.
>and and the
very methods used as cures. e.g
>cutting out disease,
Works well for acute appendicitis
(which we very rarely see these days because of better childhood health
and anti-biotics). Works fantastically for fontal lobe epilepsy, where
a microscopic cut can save a person from a
life of severe seizures every 10-15
minutes or so. Works reasonably well in early intervention in skin
cancer, breast cancer and so on where we can get to the tumor before it
has spread to other sites.
>poisoning
parasites
You would prefer death by
diarrhea/malaria/guinea worms blocking your heart muscles? Selective
poisoning is the basis of anti-microbial/protozoal therapy. By ALL
treatment modailities.
>and radiating
all else. I don't
>consider cutting to be a cure, even if the condition does not
return.
Why not? The whole point is to stop
the disease process, and save a persons life.
>The
>problem I have with doctors is that they see only the disease and
want to
>supress the symptoms.
No they want to cure it. Some
things, like Rheumatoid arthritis, we can't cure yet, but can suppress
the disease process for long enough to provide a decent quality of
life. Some things, like the flu, we can make people more
comfortable with while their body
fights it off (we have actual anti-flu drugs, but they are a bit
expensive and work best if you get them before the flu). Other things
we can cure.
>This is not a
cure. The symptoms may disappear, only
>to reappear as something else
A concrete example please.
>When you go to
a Naturapath. They treat the
>whole person. ie the whole of the body, the mind and emotions and
the spirit
>or soul. Most scientists don't even know what the soul is, and can
not
>identify with it. Am I not correct here?
No. No scientist knows what a soul
is, NOBODY knows what a soul is (or even if one exists). We have almost
40,000 years of investigation into the soul by some of the finest minds
on the planet and nobody, but nobody knows what the soul is (or if it exists). On
the other hand, quite a few scientists (eg Keith Miller, Francis Alya)
believe they have souls, they just don't pretend they know what they
are.
>When I said
that I thought it was too good to be true that I could
>successfully communicate with scientists; I did not mean that
scientists
>were not good communicators. I meant that I probably would not have
the
>ability to communicate with them.
You are. It's hard, because we think
in differnt ways, but keep at it and we can go places.
Ray posted:
Sandra,
The problem is (for Homeopathy)
there is no proof and devotees tend to have the same kind of 'faith'
attitude to the field as creationists.
Whatever proof negative to
homeopathy, 'devotees' simply refuse to accept the cold logic of
scientific testing.
If you want to make a valid
comparison between arguments pro and con, then I suggest that you
contact NATA. (National Association of Testing Authorities) and see
what they have to say.
http://www.nata.asn.au
My bet is that whatever they say,
because they have a tradition of not accepting that 1+1=3, you won't
accept their answer anyway.
And Sandra, whilst there are ample
anecdotal tales of extraordinary cures for cancers extending from
meditation to herbalism to inexplicable snake oils, as well as sheer
good luck, the potential for disaster of failure in treatment by what
amounts to little more than tap water is a cold reminder that ignoring
science for unproven alternative medicines can amount to malpractice by
neglect.
That Sandra, is precisely why
simple prayer to your god of choice is scary....
Ray
PS If it works for
you, fine, but equally so, it is the right of others to object on
rational grounds to your evangelism of an unproven panacea. Mind
you, I am prepared to accept the medical efficiency of herbalism and
even meditation, but I would still be wanting barium X-rays or CAT from
authentic, and proven, scientific medicine for diagnosis. Before
I have a 20 kilo tumour to worry about....
and:
I might add that, as much
as there have been deaths in hospitals due to incorrect or excessive
doses of pharmaceuticals, there have also been more than a few cases of
litigation where parents have been charged with causing the death of
infants through use of alternative medicine and failure to consult
traditional medical authorities.
and:
>>A doctor
has only cured me of one thing, and that was amoebic dysentery,
which was poisoned. I was poisoned, with arsenic no less.
When and where was this Sandra?
Arsenic, I believe, is a
cumulative poison like lead, and toxicity of the element is a matter of
sustained consumption over time. Small, short term dosage I
generally not poisonous.
I may be wrong, but doubtless,
you'd prefer not to have a colony of amoeba in your gastric system.
There are probably better
treatments for amoebic dysentery than arsenic in any case.
Paul Williams added:
> >>A doctor has only cured me
of one thing, and that was amoebic
dysentery,
> which was poisoned. I was poisoned, with arsenic no less.
>
> When and where was this Sandra?
>
> Arsenic, I believe, is a cumulative poison like lead, and toxicity
of the
> element is a matter of sustained consumption over time.
Small, short term
> dosage I generally not poisonous.
>
> I may be wrong, but doubtless, you'd prefer not to have a colony
of amoeba
> in your gastric system.
>
> There are probably better treatments for amoebic dysentery than
arsenic in
> any case.
I think that prescribing arsenic would be somewhat unusual...
I used to carry tetracycline, 'Fasigyn' (Tinidazole) and 'Flagyl'
(Metronidazole) This was in places where there was no medical
help. Tetracycline would cure most bacterial dysentery and some amoebic
dysentery. Flagyl was more thorough though. With Giadia
infection, only Fasigyn and Flagyl were effective.
Amoebic dysentery if left untreated is life threatening. The amoeba can
migrate to vital organs. There may be periods of months or even
years when there are no symptoms.
The usual disclaimers apply to the above and one must emphasise that to
take these drugs merely on speculation is foolish. Whenever good
medical help was available I availed myself of it. It really is best to
get the all clear from a doctor.
Amoebic Dysentery:
http://www.netdoctor.co.uk/travel/diseases/amoebic_dysentery.htm
David
Martin wrote:
Hi again Sandra,
Glad to see you're still on the
list.
You seem to have misunderstood my
original email on this topic, or confused me with someone else. I made
no mention of "traditional" medicine and was in no way supporting or
defending it; I leave that to others on the List who are far better
qualified to do so.
I was trying to point out what
seems to be a logical inconsistency in the homeopathic claim that
potency increases with dilution. As a consequence, distilled water
would be cure for all ills. You have yet to respond.
I'm well aware, of course, of the
homeopathic claim that water has a memory. If that claim is
correct then there is a great deal wrong with our present understanding
of physics and chemistry; I'm certainly prepared to support
and defend that.
Some other points from your email:
I think it unfair to claim that
"science flounders, founders frequently" on the basis that medicine
doesn't have a 100% success rate. Medicine makes no such claim; nor
should such a claim be expected. Even the simplest
biological systems are far too
complex to be understood in anything but the broadest terms. There are,
as yet, no "laws of medicine" in anything like the same sense that
there are laws of physics.
You
also criticise cures which are successful on the basis that some of
them have terrible side effects. This is a rather one sided view, since
you fail to mention that some diseases also have terrible side effects:
death, for
example.
In any case, even if "traditional"
medicine gets things wrong, that is not an argument in favour of any
alternative.
You mention the "soul". I can't
speak for "most scientists", but it's true to say that Science doesn't
recognise such an entity. Science doesn't recognise fairies either, and
for much the same reasons: although many
people are convinced they exist,
no-one has been able to provide any evidence.
Finally, I have to say that I
think your hostility towards science comes from a misunderstanding of
what science is and how the scientific process works. I hope membership
of the List will soften your attitude a little, although you should be
prepared to have your ideas subjected to stringent criticism. That is
part of the scientific process.
Jim Thornton added:
...pure water is a potent cure for all ills.
I would like to add these observations:
1. Everybody to date who has drunk water, hot, cold, distilled, mixed
with whisky or otherwise has died or will die. ;-(
2. A pie chart of how people die may change colours and the size of
individual wedges, but so far there is no missing wedge.
3. The fridge had a major impact on increasing life expectancy by
reducing the amount of salted meat consumed.
Gerald Cairnes
commented:
Hi Jim,
I haven't been able to participate
in this thread but to add to your comments people should also be
reminded that water is regarded as a suspected carcinogen. Water is
radio active, granted this is low, but water is not innocuous as are
many substances we tend to take for granted simply because they tend to
be generally accepted as safe.
Ian Musgrave wrote in reply to Donald:
At 04:58 4/09/03 +1000, DEE wrote:
>G'Day All & specially
>Ian.
>
>As you will see below, I have
snipped much leaving a statement about half a
>billion dollars. I have heard or read it before, and I get a need
to quote a
>number like it occasionally. Please could I have a confirmation
that the
>word is "billion" and not "Squillion"? If it is not too large an
order,
>could you supply URL for a place with a breakdown of the figure, a
case in
>point or alternatively a few components off the top of your own
head?
The TGA website has the figure lurking around somewhere, and it's the
standard estimate for run of the mill drugs. I can dig it up
journal references from my lecture notes (ie the lectures I give).
But, for example, a two year toxicology trial in mice alone can cost
around $50,000 to run, with personnel ( a single half time technician
will cost $30,000 over two years minimum, and then there's the costs of
running
tests, documentation etc). A large, multicenter trial in patients that
runs for 12 months will easily cost $200,000 with costs of patient
recruitment, tests, documentation etc. Anticancer trails, where you
have to follow the
patients for 5 years, will cost more. Preparing the documentation for
TGA approval alone, runs to around a 100 volumes of clinical and
preclinical data, of which there has to be multiple copies.
In a standard dug application, there will be multiple tests in
preclincial trials, at
least two
long term toxicology trials in animals, drug distribution trials, tests
in disease models, tissue culture etc. In the clinical side there will
be short term, medium term and at least one large multicentre trial.
These things add up.You won't get much change from half a billion
dollars for developing a new drug.
and to Sandra:
At 12:59 5/09/03 +1000, Sandra wrote:
>Ian,
>I have written several letters to the NCI of USA and have not
received one
>reply.
Did you include and addressed reply envelope with international
postage? The US NCI is an American organisation, and they are
swamped with enquires from US citizens, and are hard pressed to answer
them, let alone Australian citizens, whom they are not obliged to reply
to by their charter.
>All my letters were concerning
natural treatments and cures. I asked
>them to comment on Hulda Regehr Clark's two books The Cure for all
Diseases
>and The Cure for all Cancers. I also sent copies of the letters by
fax. When
>Hulda Clark was arrested and thrown into jail for advocating that
she could
>cure cancer.
She was arrested for fraud. Fraudulently claiming you can cure cancer
is one of the more unpleasant types of fraud.
http://www.quackwatch.org/01QuackeryRelatedTopics/Cancer/clark.html
Here is Hulda Clark's explanation of cancer
"All cancers are alike. They are all caused by a parasite. A single
parasite! It is the human intestinal fluke. And if you kill this
parasite, the cancer stops immediately. The tissue becomes normal
again. In order to get cancer, you must have this parasite. . . ."
And we know this is wrong. If it were true, the we couldn't culture
cancer cells, the minute cancer cells were taken out of the body and
away from the influence of the parasite, they should revert to normal.
In my lab I have cancerous nerve cells that I have been growing for
years, that have never reverted to normal, despite being years away
from any alleged parasite influence.
Cells in the body go through co-ordinated cycles of growth and death.
Cancer is caused by mutations to the genes that control cell
growth and cell death, with the result that the affected cells grow
uncontrollably. The cells have several backup, so you need
several mutations usually (which is why cancer is generally a disease
of old age, as it takes time to accumulate multiple mutations in the
growth machinery. The mutations are mostly spontaneous, although is
some cases, they can be induce by viruses (eg Feline Leukaemia virus).
An example is Chronic Myelid Leukaemia (CML), it is fairly unusual in
that a single (rather than multiple), recurrent mutation is responsible
for it. In CML there is a cross over mutation between chromosomes 9 and
22, one of the chromosome 22's is truncated (and its distinctive
appearance is diagnostic of CML, it is known as the Philadelphia
chromosome), and has a bit of chromosome 9 fused to it. The chromosome
fusion fuses two genes BCR and ABL, that code for growth controlling
genes. The fused gene, known somewhat imaginatively as BCR-ABL,
produces a hybrid growth control gene that is permanently switched on,
leading to uncontrolled growth of white blood cells.
Now we can demonstrate the Philadelphia chromosome in CML pateinst,
find the mutant BCR-ABL gene in their cells, grow the mutants cells
effectively forever in cell culture. Furthermore, when we inhibit the
mutant BCR-ABL gene product, the cell growth stops, and a synthetic
drug, glivec, which blocks the BCR-ABL gene product is wildly
successful at stopping CML in humans, with greater than 80% success.
Those that don't respond have mutant BCR-ABL's that don't bind the
drug, or have secondary, downstream mutations. (At this point, I should
link you to my lecture handouts on CML and BCR-ABL, but copyright
considerations prevents me from doing so)
In contrast, in western societies intestinal fluke infection is
virtually unknown these days (and, as an ex clinical biochemist, we can
diagnose the presence of flukes quite easily, it's something I used to
do).
Now contrast the two explanations, in one, the conventional
explanation, we can demonstrate the mutation in all cases of CML, and
we can predict that attacking the mutation stops the disease in the
test tube and real humans and we can demonstrate the prediction in
careful scientific trials. We can predict that cancerous cells will
remain cancerous when taken outside of the body, and they do. In the
Hulder Clarke explanation we have a causative agent that is not found
in the vast majority of cancer victims, and a prediction that cancer
cells taken outside the body will revert to normal cells, which we know
is wrong. We have no careful clinical trails of the
supposed treatment, and no follow up of any treated patients.
Which explanation has
evidence behind
it?
>I wrote again and asked them if
there was something they could
>do for her. No reply!
The NCI is an organisation for funding research into cancer, and
providing information about cancer, what did you expect them to do,
they have no legal powers.
>After visiting their Website, I
realised that they are not the least
>interested in natural cures.
Simply not true, there is quite a bit of information on "natural" cures
http://www.nci.nih.gov/cancerinfo/treatment/cam
And descriptions of trials NCI researchers are conducting into
"natural" cures
http://cis.nci.nih.gov/fact/9_14.htm
>If it is not radiation, chemo
therapy,
>MammoSites and the like or drugs, they don't want to know about it.
So why are they conducting trials of "natural" therapies? If you search
through the site, you will find information about Taxol, for example, a
natural product from Yew trees which is improving cancer survival in
breast
and other cancers.
They also conduct research into cancer prevention
http://www.nci.nih.gov/cancerinfo/prevention-genetics-causes
>This is
>a very narrow view. How can drugs ever be superior to natural?
First off natural products ARE drugs. Anything administered to the body
that causes a change in function is a drug. What conventional medicine
administers as drugs are purer, and given in known doses, than natural
products but quite often they are just purified natural products (eg
digitalis from foxglove, taxol from Yew trees), or modified versions of
them (pseudoephedrine vs ephedrine for colds).
Furthermore, we can modify natural products so that they are more
effective, have fewer side effects (theophilleine vs caffeine for
asthma, isoprenaline vs adrenaline for asthma again). We can synthesise
drugs of a completely different structure that work better than the
natural product (RX82102 vs Yohimbine at alpha2 adrenoceptors as
vasodilators, rofecoxib vs salicylic acid from willow bark, rofecoxib
will relieve pain better than
willow bark and won't cause the massive gastric bleeding that effective
doses of willow bark does in some patients). Captopril is far better at
controlling blood pressure than natural safortoxin. We can also
administer
drugs in precise doses so that we can take into account patients
metabolism.
As another example, take wormwood, the "natural" anti-helementhtic
given by Hulda Clark as her "cure" for cancer (and all diseases).
Wormwood is highly toxic, has components (notably thujone) that cause
fairly nasty side effects, (including brain damage). Modern synthetic
anti-helemintics can kill off the worms without causing brain damage
(or most of the side effects of wormwood, which is banned as a
dangerous substance by the
Australian TGA).
Just because a substance is "natural" does not mean that it is
effective, or free from harm. A wide range of natural products can have
quite nasty, even deadly side effects (eg St Johns Wort, used for
depression, can cause lethal interactions with other drugs, some
Chinese medicines used in influenza (eg Mua Huang) can cause life
threatening hypertension).
>If a person
>has tried every natural therapy and none of them worked, then drugs
etc.
>should be used as a last resort. Okay, jump up and down and scream
at me, or
>be sarcastic--whatever, but nothing will convince me that unnatural
is
>better than natural.
Not even
evidence?
>Or that synthetic is better than
organic.
There is no difference between synthetic and organic chemicals. Vitamin
C is vitamin C whether synthesized in an orange or in a test tube.
Their properties are identical (and we know this because of experiments
carried
out with synthetic vs natural vitamins).
>The reason scientists have not got
the proof they need for homeopathic
>remedies is because the persons used in the trials were not highly
evolved
>(spiritually) enough for it to be of benefit.
This is a new one to me, and I have hung around a fair few homeopaths,
and spent the odd idle hour in Klinikum Steglitz reading homeopathy
journals on rainy afternoons during my post-doc in Germany (well, after
my brain began to melt from reading about GTP-binding proteins, I
needed a break). Its also completely at variance with the basic
principle of homeopathy (like cures like, no mention of spiritual
evolution in that pricinple)
>I believe it to be quirte true
>that a lower evolved soul can not benefit from homeopathic
remmedies.
Then why do they have homeopathic remedies for dogs and cats then?
>Also
>an overly sceptical person can block the healing process and this
could be
>transfered from the scientist to the patient.
This is where conventional medicine has the advantage, antibiotics,
insulin and anti-hypertensives work without regard to the skepticism of
the taker, or the state of evolution of their soul.
>So with a combination of a
>less than highly evolved person being trialed and a highly sceptal
>scientist, what hope have you got?
This raises an interesting question, how does one reliably detect an
"evolved soul"? When glivec doesn't work, we can sequence tha patients
BCR-ABL gene to se if it is glivec resistant quite reliably, but what
criteria does a homeopath reliably use to evaluate the state of ones
soul? If ther are so few "evolved" people, who did homeopaths find any
working cures in the first place?
And when non-sceptical homeopaths do the trials, and find no effects
also. what does this mean?
>A person must have reached a
certain level of awareness for homeopathic
>remedies to work.
A reference to this statement please, I have never heard this from a
homeopath, nor read of it in any homeopathic journal or textbook.
>Please note that lower class,
uneducated people are not
>attracted to these types of remedies.
Evidence for this statement please. My observation is just the opposite.
>They run to the doctor at the first
>sign of illness and do NOT take responsibility for their health!
Again, this is not my experience, if Chris Lawson were still about, he
would have been able to comment on this with more authority. Hmm, I
might check if our local alternative medicine group has statistics on
this.
Anne
added:
> >Please
note that lower class, uneducated people are not
>attracted to these types of remedies.
> Evidence for this statement please. My observation is just the
opposite.
> >They run to the doctor at the first
> >sign of illness and do NOT take responsibility for their
health!
>
May
i just add more common sense to the the topic (thanks to the regular
natterers for being polite whilst educating the anti science members of
the public...) as usual its been entertaining It is the lower
class that would find it hard to send themselves or other members of
their family to the doctors as you see the cost is sometimes not
available
Bruce Harris posted:
Seems to be a bit of discussion going on about the efficacy of
homeopathy.
Now generally I'm as sceptical as the next bloke about most things, but
it so happens that in the case of homeopathy, I have proof that it
works. But to put the proof into context, I have to set the scene with
a small tale.
A few years ago, my business partner from Melbourne (who I'll refer to
as Neil, that being his name), and I from Qld, descended upon Sydney
for a two-day directors' meeting of our small company. Being
penny-pinching
tightwads, to coin a tautology, we decided to share a hotel room,
having first openly and honestly each declared to the other that
according to the testament of our respective families, we were both
heavy snorers.
At the end of the first gruelling day of discussion and
decision-making, we had a few beers, a large dinner, a few bottles of
wine and a few games of chess (it was a board meeting, after all), then
went to bed. Neil's family
had spoken the truth. He snored. When my Granddad was alive, he had a
farm. And on that farm he had a tractor. Tractors, at least back
in the 60s, were not renowned for their silence. When the need arose,
my uncle would hook a belt to the tractor and attach the other end to
the chaff-cutter, and would proceed to cut chaff. I cannot imagine a
better impersonation of the combined sound of the tractor and the
chaff-cutter than Neil's snoring that night.
At the end of the second equally gruelling day, we again had a few
beers, a large dinner, a few bottles of wine and a few games of chess.
But this time, before retiring, I also polished off, alone and
unassisted, the outrageously expensive 5-oz bottle of whisky from the
mini-bar. Neil didn't snore that night! This proves that all that is
required to cure Neil's snoring is for whoever is sharing his sleeping
quarters to have a few nips of whisky before bed. (His wife was
singularly unimpressed when I told her of this remedy.)
So back to homeopathy. My dear wife, who as aforesaid is of the opinion
that I am not a silent sleeper, is a bit of a believer in alternative
medicines, herbalism etc. A few months ago, by pure chance, I saw on
the shelf of a
chemist shop a bottle of homeopathic medicine to alleviate snoring. I
bought it. Since then, the following conversation has been a regular
part of our lives. It's not quite this blatant, but this is its essence:
Me: Did my snoring disturb you last night, my precious honey-turtle?
She: Did you take your no-snore drops?
Me: Indeed I did.
She: Actually, you didn't snore too much. It was audible, but not
disturbing.
So there you have it. Just as my whisky nightcap cured Neil's snoring,
my wife's belief that I have taken some homeopathic medicine cures mine.
As a serious footnote: When I first learnt about the placebo effect a
few decades ago, I wondered why conventional medicine doesn't try to
harness it rather than regard it as a nuisance. And what could be a
better inducer of the placebo effect than a few drops of a solution
which has been diluted to such a degree that the "active" ingredient is
no longer present?
Paul Williams
wrote:
>And what
could be a better inducer of
> the placebo effect than a few drops of a solution which has been
diluted to
> such a degree that the "active" ingredient is no longer present?
>
Hi Bruce, all,
I know this would be a question
for Chris Lawson or Ian Musgrave...
Neverthesless...
IMHO:
I don't think that 'conventional'
medical practitioners would regard the placebo effect as a nuisance at
all (or they shouldn't)
Doctors quite often prescribe
anti-biotics for the common cold.
One may argue for prophylactic
reasons - regarding possible secondary bacterial infections.
One may also argue that they are
prescribing placebos but they (the antibiotics) do have known clinical
applications.
Distilled water (or close to this)
has no known clinical application - relating to disease. And no
possibility of any. To prescribe something that has no therapeutic
value with no possibility of helping to alleviate symptoms or slow or
stop disease progress, that has no possibility of having any physical
effect at all, would be ethically wrong, in my opinion.
There are many effective drugs
which can be prescribed - the placebo effect will also work with these.
Where there is a theoretical
chance of a treatment working for reasons not yet fully understood, I
could see this being tried.
But.
If one's doctor lies to one - I
believe it would definitely be time to find another doctor.
Podargus replied:
I suspect, from personal observation, that doctors probably do in some
cases, such things as pain killers. But as you say deliberately
prescribing a medication as a placebo does raise ethical questions.
We had a neighbour who kept MIMS beside the phone, the better to argue
with her, or her kids doctor. If she didn't get what she wanted
she just shopped around. After consulting a couple of Drs and
MIMS she would have gleaned enough info to present with appropriate
symptoms.
As an aside. I saw a reference recently, perhaps NS, which said
something along the lines that placebos only work on some illnesses.
Sandra
wrote in reply to Ray:
> I might add
that, as much as there have been deaths in hospitals due to
> incorrect or excessive doses of pharmaceuticals, there have also
been more
> than a few cases of litigation where parents have been charged with
causing
> the death of infants through use of alternative medicine and
failure to
> consult traditional medical authorities.
Ray,
These children may have died
anyway, even if they had been admitted to hospital. The litigation rate
in these cases is very low compared to deaths in hospitals. When a baby
dies from a midwife's delivery, all hell breaks out and the media floggs it to death,
but thousands of babies die in hospitals and they are not even reported.
and to Paul:
> I used to carry tetracycline,
'Fasigyn' (Tinidazole) and 'Flagyl'
> (Metronidazole)
> This was in places where there was no medical help.
> Tetracycline would cure most bacterial dysentery and some amoebic
> dysentery. Flagyl was more thorough though.
> With Giadia infection, only Fasigyn and Flagyl were effective.
>
> Amoebic dysentery if left untreated is life threatening. The
amoeba can
> migrate to vital organs.
> There may be periods of months or even years when there are no
symptoms.
>
> The usual disclaimers apply to the above and one must emphasise
that to
> take these drugs merely on speculation is foolish.
> Whenever good medical help was available I availed myself of it.
> It really is best to get the all clear from a doctor.
Paul, I was started on Tetracycline and then progressed to Flagyl. When
further enema tests showed that the parasite was still in my system, I
was then prescribed Arsenic. I had had the parasites for more than a
year before I was diagnosed. This was the Bangkok Christian Hospital in
1972.
Margaret Gladstone wrote:
When a baby dies from a midwife's
delivery, all hell breaks
> out and the media floggs it to death, but thousands of babies die
in
> hospitals and they are not even reported.
> Sandra
i
I'm not a scientist nor do I profess to any medical knowledge but the
last sentence could be interpreted that hospitals have some role in the
deaths of "thousands of babies".
My experience of hospitals is that they are staffed by many dedicated
and compassionate people who are paid peanuts. It is upsetting
when a patient they are caring for dies and even more so when that
patient is a baby or
child.
Sandra
wrote to Ray:
Ray,
I meant to answer this some days
ago, but couldn't find your post. I decided to look up my book on
Homoeopathic First-Aid Here is what it says: "Tinnitus-Attend to the
cause; otherwise treatment is a waste of time (same line of argument as
for the treatment of Anosmia). It is logical to try to make the buzzing
in the ears disappear only by curing the cause of it (impairment of
such-and-such a part of the ear and the cause of that impairment); for the buzzing is just an
alarm signal announcing that the ear is becoming or is abnormal. The
buzzing disappears only when the ear is brought back to the state in
which it was when the buzzing started; that is plain logic."
High-speed Healing says: "Just
relax. Use relaxation therapy and biofeedback to reduce stress, which
often exacerbates tinnitus, and to get you in better touch with your
body. Seek professional assistance in alleviating
psychological results of tinnitus,
such as depression or anxiety. Keep a positive attitude and assume
control. If people have the attitude that tinnitus is wrecking their
lives, it probably will."......."Tinnitus doesn't have one cause; many
factors aggravate it. Allergies to food and other things can make
tinnitus worse. Temporomandibular disorder (TMD) can also aggravate it.
For more information you can write to the American Tinnitus
Association, PO Box 5, Portland OR
97207."
"Recent research has shown that
exposure to loud noise in conjunction with certain chemicals in creases
e.g. carbon mon-oxide or certain other chemicals that interfere with
oxygen delivery to the ear are the most
vulnerable population."
My suggestion is to dry you ears
with a hair-drier after every shower and washing of hair, due to the
fact that fungal infection breed in dark moist places.
My book on Dr. Schuessler's
Biochemistry suggests: Beating in the ears-Silicea. Humming in the
ears-Natrum Mur. Noises in the head and ears with confusion- Kali
Phos. Singing in the ears Nat Mur. Whizzing and ringing in the ears with diminution of hearing
Magnesia Phos.
I hope some of this may be of help.