- Harding was the first president to speak over the radio.
- He was the first president to visit Canada. He stopped in Vancouver on his way to Alaska. He was also the first president to visit Alaska.
- He suffered nervous breakdowns at the age of 24 and had to spend some time in a sanitarium.
- He had a pet canary named "Bob" and a dog named "Laddie Boy."
- Harding played poker at least twice a week. He once gambled away an entire set of White House china, dating back to Benjamin Harrison's time. His advisors were given the nickname of the "Poker Cabinet" because they all played poker together.
- Harding was the first president to ride to his inauguration in a car.
Harding was the first president to have a radio.
Both of Harding's parents were doctors.
He was also the first newspaper publisher to be elected into the presidency.
Warren G. Harding was the first president to have a public golf course named after him.
- His mother called him "Winnie."
- He was named after his great-uncle the Reverend Warren Gamaliel Bancroft, a Methodist chaplain at the Wisconsin State Prison.
- Out of all the presidents, Harding had the biggest feet. He wore size fourteen shoes.