Career Leaders for Home Runs
Minimum of 3.1 PA/G, 1.0 IP/G, and 0.1 decision/G for career leaderboards for rate statistics.
| Rank | Player | Home Runs |
| 1. | Albert Pujols | 227 |
| 2. | Alex Rodriguez | 222 |
| 3. | Manny Ramirez | 219 |
| 4. | Miguel Cabrera | 212 |
| 5. | Adam Dunn | 181 |
