Career Leaders for Runs
Minimum of 3.1 PA/G, 1.0 IP/G, and 0.1 decision/G for career leaderboards for rate statistics.
| Rank | Player | Runs |
| 1. | Alex Rodriguez | 682 |
| 2. | Chipper Jones | 636 |
| 3. | Albert Pujols | 633 |
| 4. | Miguel Cabrera | 605 |
| 5. | Manny Ramirez | 565 |
| 5. | Todd Helton | 565 |
