Single-Season Leaders for Runs
Minimum of 3.1 PA/G, 1.0 IP/G, and 0.1 decision/G for single-season leaderboards for rate statistics.
| Rank | Player | Runs | Year |
| 1. | Barry Bonds | 86 | 2002 |
| 2. | Barry Bonds | 77 | 2003 |
| 3. | Jeff Bagwell | 76 | 2004 |
| 3. | Alex Rodriguez | 76 | 2006 |
| 5. | Manny Ramirez | 75 | 2001 |
| 5. | Barry Bonds | 75 | 2005 |
