Career Leaders for Strikeouts
Minimum of 3.1 PA/G, 1.0 IP/G, and 0.1 decision/G for career leaderboards for rate statistics.
| Rank | Player | Strikeouts |
| 1. | Adam Dunn | 927 |
| 2. | Alex Rodriguez | 813 |
| 3. | Miguel Cabrera | 775 |
| 4. | Ryan Howard | 721 |
| 5. | Manny Ramirez | 720 |
