Single-Season Leaders for Strikeouts
Minimum of 3.1 PA/G, 1.0 IP/G, and 0.1 decision/G for single-season leaderboards for rate statistics.
| Rank | Player | Strikeouts | Year |
| 1. | Jack Cust | 131 | 2008 |
| 2. | Jason Bay | 127 | 2005 |
| 3. | Marcus Thames | 116 | 2008 |
| 4. | Jim Thome | 114 | 2004 |
| 5. | Adam Dunn | 113 | 2013 |
