Runaway Train: Sully boards a train with newly freed Cloud Dancing, but robbers are also aboard.
Having It All: While Mike tries to juggle work and child-care responsibilities, Colleen prepares to leave town after she's accepted to college.
Malpractice: A baby dies while under Mike's care, and the parents sue her for malpractice.
All That Glitters: Colleen returns from Denver in the company of a dazzling singing star (Barbara Mandrell) who wows the town.
Los Americanos: Tragedy strikes Mexican-American newlyweds who purchase the ranch near the homestead; Robert E and Grace consider adopting Anthony.
Last Dance: Sully is offered a job in the new Yellowstone National Park; Matthew and Emma reach a turning point.
Right or Wrong: While Jake and Preston campaign for mayor, Sully elects to rescue an Indian being held prisoner by the Army.
Remember Me: A lonely old prospector turns out to be Jake's father, who abandoned his family years ago.
Legend: Mike, Sully and Matthew team with a legendary lawman (Willie Nelson) to track down bank robbers; Brian plays Cupid for Teresa (Michelle Bonilla) and Jake.
The Tempest: Mike learns that Andrew is opening his own practice; and Preston's father arrives for the hotel's Thanksgiving opening.
Separate But Equal: Grace and Robert E's efforts to enroll Anthony (Brandon Hammond) in school run into racial obstacles.
A Place to Die: A deadly outbreak is traced to Mike's clinic, and it threatens to destroy her practice.
A Season of Miracles: The joy of the Christmas season is diminished by Rev. Johnson's sudden blindness, a condition for which Mike can find no cure.
The Dam: Sully and Preston oppose the construction of a dam — but the law, in the form of Matthew, stands against them.
Farewell Appearance: Mike receives a surprise visit from her beloved uncle (David Ogden Stiers), a pianist who still quietly grieves for the son he lost at Gettysburg.
The Most Fatal Disease: Kid Cole and Sister Ruth are escorting mail-order brides to California, where, Mike learns, the couple intend to divorce.
Colleen's Paper: Mike recalls significant medical cases (via clips from previous shows) for the benefit of Colleen, who's writing a paper for college.
Between Friends(Two Part Episode): Sully's closest friend, Daniel Simon, falls in love with Dr. Mike when he comes to Colorado Springs for a visit. Sully and Dr. Mike are going through a bad time struggling to scrape up enough money to make the month's bank payment on their loan.
Hostage: Mike, Brian and baby Katie are held hostage at the homestead by a pair of bank-robbing brothers (David Carradine, James Keach).
The Body Electric: Poet Walt Whitman visits Colorado Springs, but when townsfolk hear rumors about his sexual orientation, they shun him.
Before the Dawn: When Horace makes a suicide attempt after signing his divorce papers, Mike prescribes a visit from Myra and his daughter as an antidote for his melancholy.
Starting Over: Mike's suffragette sister (Alley Mills) shares her passionate feelings with Loren in more ways than one.
His Father's Son: Feeling neglected, Brian acts out in adolescent fashion. Meanwhile, Andrew sells a specious remedy for the resort clinic.
Moment of Truth (Two Part Episode): Part 1: After soldiers give Cloud Dancing a severe beating, Sully plots an escape for the tribespeople on the reservation. Part 2: Sully and Cloud Dancing are on the run from the Army after the reservation rebellion.
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