Hathaway assists Joi Abbott (recurring guest star VALERIE MAHAFFEY), who faints in the cafeteria. Tests reveal Joi has anemia. Joi attends to her son, Ricky (recurring guest star KYLE CHAMBERS), who has a degenerative neurological disease.

Hathaway persuades the exhausted mother to accept some outside help. Lee tells Greene many fascinating stories about her past and tells Hathaway about Greene's incredible sexual exploits. A curious Greene discovers Lee's a fake and that Anspaugh never checked her credentials. When Lee realizes Greene is suspicious, she locks him in the cat scan room with an agoraphobic patient (NANCY LENEHAN). A disappointed Hathaway learns Greene never had sex with Lee.

Greene receives an application from NASA to become an astronaut. He discovers that a fellow medical school alumnus is part of an upcoming mission and recommended Greene for the team. Carter's exposure test to TB (tuberculosis) proves positive, and he must take medication for six months. Lucy agrees to go on a date with Dale, who confides to Carter that he hopes to have sex with her.

A woman (SARA MORNELL) about to give birth is rushed to the hospital by her husband (SCOTT MOSENSON), who crashes into another auto en route. The driver of the other car is also transported to County General and dies. The husband gets arrested because his blood alcohol level is above the legal limit, and he misses the birth of his child.

Benton successfully performs an appendectomy on Dr. Parks' 8-year-old granddaughter, Gwen (TARA KLEIGER). A day-care worker suggests to Benton that Reese requires a "special needs" environment because he's exhibiting problem behavior. A cop, Reggie Moore (recurring guest star CRESS WILLIAMS), who Jeanie treats for a minor injury, asks her on a date. Eventually, she accepts. And the staff prepares to work on victims in a commuter plane crash--but there are no survivors.