A sleep deprived Carter experiences mood changes, and Chen worries about him. He gives a patient the wrong intravenous medication. When the patient experiences a drug reaction, Carter administers the antidote but doesn't admit to the error. Chen implores Greene to talk to Carter. Remarkably, Carter willingly agrees to see a therapist. Hathaway takes care of a 38-year-old, end-stage cancer patient, Shelagh O'Brien (RACHEL SINGER). Shelagh's husband, Steve (LOUIS MUSTILLO), and their two young daughters accompany Shelagh. Shelagh has a DNR (Do Not Rescucitate) order. Later, with Steve at her side, Shelagh stops breathing. Steve begs Hathaway to help bring her back because his daughters need to say good-bye. Hathaway enlists Kovac's help without telling him Shelagh is Weaver's patient. They successfully resuscitate her. When Weaver finds out, she's furious at both Kovac and Hathaway. And Kovac becomes angry at Hathaway. They resolve the problem and kiss. Later, Hathaway confesses she still loves Ross. Shelagh dies with her family by her side. After witnessing the wonderful, close family bond Shelagh and Steve shared, Hathaway realizes she must see if she and Ross are meant for each other. She travels to Seattle, Washington, and reunites with her soul mate, Dr. Doug Ross (GEORGE CLOONEY - "The Perfect Storm"). The happy couple embrace and kiss.

Greene boxes the unused medical supplies in his apartment. Corday explains to Malucci that the hospital staff doesn't respect him as a physician, and he needs to get serious about his commitment to medicine. Under Malucci's supervision, Abby fails to properly diagnose a woman with a tubo-ovarian abscess, and the patient almost dies. Corday encourages Greene to give his mother's pearls to Rachel. The gift delights his daughter