Weaver tells Greene that she will consider supporting Lewis for a position as chief resident if Greene will help Weaver become an emergency room attending physician. Later, Greene agrees to care for the children of a reformed prostitute, Loretta, for one night while she undergoes more cancer surgery. Iris and Greene continue their relationship.

When Shep is investigated for getting into a fight with the brother of a gunshot victim, Hathaway reluctantly lies to protect Shep because she did not witness the entire incident. She worries about Shep's mental state.

Carter learns some new basketball trivia from a 10-year-old female basketball player who needs a liver transplant, which prevents her from playing in a tournament.

Jeanie's estranged husband, Al, thinks he has influenza, but Jeanie must give him worse news: He contracted HIV. Jeanie must also undergo an HIV test herself.

Lewis, who is consulting a therapist because she misses Susie, overreacts when a young mother brings her obviously abused child to the emergency room. Weaver must subdue Lewis.

Police officer Al Grabarsky (recurring guest star MIKE GENOVESE) and nurse Lydia Wright (recurring guest star ELLEN CRAWFORD), who have been dating for some time, get engaged to be married.

Series star ANTHONY EDWARDS directed the episode.