Benton allows Carter to do his first unsupervised surgery on an alcoholic, Ed (JOHN FINNEGAN). Trying to impress Harper, Carter accidentally perforates Ed's liver, necessitating emergency surgery by attending physician Angela Hicks (recurring guest star CCH POUNDER). The patient dies of heart failure, Carter's first loss.

In her last run with the paramedics, Hathaway helps Shep haul in an obese mentally ill man (JOE COSTANZA), who dies of a stroke. Later, Shep struggles to bring in a man on illicit drugs. Hathaway distracts the patient while Shep sneaks up and injects him with a sedative. At the end of the day, Hathaway and Shep kiss and plan a date.

Lewis and Weaver continue to argue, calling upon Greene to mediate when they disagree on a medical procedure. Greene supports Weaver. Chloe, high on drugs or alcohol, leaves town without baby Susie. Benton still wants Jeanie to tell her husband about their love affair, but Jeanie avoids Benton. Rather than tell her husband, she feels that she must end the affair.

Nurse Goldman (recurring guest star VANESSA MARQUEZ) interviews Greene and the other doctors for the nursing newsletter. Greene tells his wife, Jennifer (recurring guest star CHRISTINE HARNOS), that he wants to stay at Ross' home a few nights a week because the commute from Chicago to Milwaukee is too long. On Greene's first night at Ross', he meets a stewardess, Hulda (recurring guest star NICOLE NAGEL), who is romantically involved with Ross.