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Bupropion ( Amfebutamone,  Wellbutrin )

Interactions

Name / Class Effect of Interaction
Antidepressants
( Tricyclics ):
  • 1. ALL
 Increase risk of having major seizures
Carbamazepine. May increase the effects of Carbamazepine
Increase risk of having seizures
Cimetidine. May increase bupropion effects
Clozapine. Increase risk of having major seizures
Fluoxetine. Increase risk of having major seizures
Haloperidol. Increase risk of having major seizures
Levodopa. May increase the effects of Levodopa
Increase risk of having seizures
Lithium. Increase risk of having major seizures
Loxapine. Increase risk of having major seizures
Molindone. Increase risk of having major seizures
Monoamine Oxidase Inhibitors
( MAO ):
  • 1. ALL
 May increase bupropion levels
( Bupropion Toxicity )
Phenothiazines:
  • 1. ALL
 Increase risk of having major seizures
Phenytoin. May increase the effects of Phenytoin
Increase risk of having seizures
Thioxanthenes:
  • 1. ALL
 Increase risk of having major seizures
Trazodone. Increase risk of having major seizures

How it works:
Increases the levels of norepinphrine and dopamine and is primarily a stimulant to brain activity.