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Illinois 145 is a north-south route in southern Illinois that serves as an alternate to US45 (hence the "45" in its number). It runs from Harrisburg to Metropolis.

Intersections from north to south:

IL145 begins at US45 in Harrisburg, on a stretch where IL145 is multiplexed with IL34

Signage along US45 southbound

IL34 breaks off to head southeast

IL147

IL146

IL145 ends at US45 near I-24 by Metropolis.

It passes through these towns: Harrisburg and Eddyville.

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