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William and Madison's Science Project
How Penicillin Works

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How Penicillin Works

Penicillin kills bacteria by interfering with the
ability to synthesize cell wall. In the movie
sequence, Escherichia coli were incubated in

penicillin for 30 minutes. The bacteria
lengthen, but cannot divide. Eventually the
weak cell wall ruptures.

Improper antibiotic use selects for
populations of antibiotic-resistant pathogens.
Some bacteria avoid the effect of penicillin by
the production of penicillinase, an enzyme
that destroys penicillin.

Jump to the demonstration movie now.

Movie (penpop.mov) Courtesy Of Cells Alive.com

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