--Merge onto I-26 E.
--Take the US-601 SOUTH exit
--Merge onto US-601 S.
--US-601 S becomes US-601 S/US-21 BR S.
--Stay straight to go onto US-21 BR.

From I-26 West (Charleston, SC):

--Take the I-26 WEST ramp.
--Merge onto I-26 W.
--Take the US-301 SOUTH exit
--Merge onto US-301 S.
--Turn LEFT onto US-21 BR.

From I-95 North (Florence, SC):

--Take the I-95 SOUTH exit
--Merge onto I-95 S.
--Take the exit
--Merge onto US-301 CONN W.
--US-301 CONN W becomes US-301 S.
--Turn LEFT onto US-21 BR.

From I-95 South (Savannah, GA):

--Merge onto I-95 N.
--I-95 N becomes I-95 N/US-17 N.
--Stay straight to go onto I-95 N.
--Take the I-26 WEST exit
--Merge onto I-26 W.
--Take the US-301 SOUTH exit
--Merge onto US-301 S.
--Turn LEFT onto US-21 BR.

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