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Illinois 140 is an east-west route whose eastern half follows along US40 closely and whose western half skims the northern reaches of the metro-east, passing right through Alton.

Intersections from east to west:

IL140 begins in the east US40/ US51/ IL185 at Vandalia

US40 near Mulberry Grove

IL127 joins from the south at Greenville

IL127 leaves to the north

IL160

IL4

I-55

IL157 at Hamel

IL159

IL111 joins from the south by Bethalto

IL140 has an interchange with IL3 where IL111 follows IL3 north

IL140 ends in Alton at IL143 just a block east of that route's western end at US67.

It passes through these towns: Vandalia, Mulberry Grove, Greenville, Alhambra, Hamel, Bethalto, Alton.

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