 |
Abstract of articles from |
| Indian Journal of Tuberculosis | |
| reproduced with kind permission |
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Vol 54 
No 1Oct 2007
ISSN 0019-5707 |
Original articles
- Evaluation of an intermittent six month regimen in new pulmonary tuberculosis patients with diabetes mellitus
- Annual risk of tuberculosis infection in Andhra Pradesh,India antigens in cured spinal tuberculosis patients and their contacts
- Simple direct drug susceptibility tests on sputum samples for early detection of resistance in tubercle bacilli
- Status report on RNTCP
Case report
- Tuberculosis presenting as osteolytic soft tissue swelling of skull in HIV positive patients
- Tuberculosis brain abscess in a patient with HIV infection
Short communication
Background: The treatment of tuberculosis(TB)with Category I regimen of the Revised National Tuberculosis Control Programme(RNTCP)for patients with diabetes mellitus(DM)needs evaluation
Objective: To assess the cure and relapse rates in 3 years,among the new smear positive patients with Type II DM(DMTB)treated with CAT I regimen(2E3H3R3Z3/4R3H3)of RNTCP 3
Methodology: TB suspects attending the diabetology units and the TB Rsearch Centre(TRC) Chennai wre investigated.Eligible DMTB cases were enrolled.Baseline estimation of cardiac,renal,liver function tests and glycycosylated -HBA Ic were undertaken.Allpatients received 2E3H3R3Z3/4R3H3)under supervision aat TRC.Clinical and sputum(smear and culture) examinatiations and monitoring of diabetic status were undertaken every month upto 24 months,then once in 3 months upto 36 months. Reesults: Of 100 patients admitted,seven were excluded for various reasons for analysis. Of 93 patients,87 (97%)had a favourable response at the end of treatment.Preand post treatment mean glycosylated HBIc were 9.7% and 8.4% (7% poor control).During follow-up period 6 died and 1 lost to follow up.of the remaining 4 relapsed.
Conclusion CAT I regimen,recommended for all the new smear positive patients in the Indian TB programme is effective in the treatment of DMTB pateints,despite poor control of diabetes.
Indian J Tuberc 2007 2007;54:168-176
V.K.Chadha,P.Kumar,A.V.V.Satyanarayana,L.S.Chahan,J.Gupta,S.Singh,V.Mahesh,LakshmiNarayana,J.Ahmed,R.Srivatsava,P.Suganthi and G.Uma Devi
Background There is paucity of information on epidemiological situation of tuberculosis(TB) in Andhra Pradesh.The DOTS strategy under the Revised National Tuberculosis Control Programme(RNTCP)in the year 2002 cover the s entire state by 2005.
Objectives To estimate the prevalence of tuberculous infection among children 5-9 years of age and to compute the average annual risk of tuberculosis infection(ARTI)from the estimeated prevalence.
Methods A cluster sample house based tuberculin survey was carried out in a representative sample of children between 5-9 years of age.The clusters were selected by a two stage sampling procedure.At first stage, 5 districts were selected by probabilty proportional to population size(PPS)method.Deepending upon child population ratio,32 clusters allocated to each district were further subdivided into rural and urban clustere selected by simple random sampling.A total of 3636 children,irrespective of their BCG scar status,were tuberculin tested using 1 TU PPD RT 23 with Tween 80 and the maximium transverse diameter of induration was measured about 72 hours later.
Results: The prevalence of infection estimated by mirror image technique using observe mode of reactions attributable to infection with tubercle bacilli at 20mm was 9.6%(95%) CI:8.0-11.2).The ARTI was computed at 1.4% (95% CI:1.1-1.6)
Conclusion: Survey findings indicate a fairly high rate of transmission of tubercle bacilli.
Indian J Tuberc 2007 2007;54:177-183
Sarah Mathew,S.M.Nalini,Fathima Rehman,Aszhagar Dastageer,V.Sundaram and C.N.Paramasivan
Background Direct sensitivity test either by ssputum conceentrate(DS)or swab method (DSM)set up along with the primary culture would avoid the delay of 4 or more weeks required for the indirect test.A comparison of these two methods against the standard indirect sensitivity method uunder routine laboratory conditions is necessary to prove their merit.
Method Smear positive sputum samples were aliquoted and sensitivity tests were set up by both the direct methods as also an indirect test set up from the primary culture of the same sample.
Results: The agreement with the indirect test results for isoniazid(INH)ranged from 97-98% for the DS method and 93-97% for the DSM method.The corresponding figures 96-98% by the DS and 94-99% by the DSM method for Rifampicin(R). The agreement was less satisfactory for ethambutol(EMB)
Conclusion This study showed that direct sensitivity tests such DS and DSM methods can dect most of the culture resistant to INH and R(MDR)from the time growth appears on the primary culture,even as early as the second week of setting up the tests
Indian J Tuberc 2007,54,184-189
A.K.Tripathy,N.Gupta,M.Khanna,R.Ahmed and P.Tripathy
We present a clinical case report of a 40 year old HIV positive male patient presenting with fever,cough with expectoration and osteolytic,cystic,multiple soft tissue swellings of skull(aspirate showing AFB.The various clinical possibilities are discussed along with interpretation of subsequent investigations.
Indian J Tuberc 2007,54,193-195
K.Kaushik,S.Karade,S.Kumar and K.Kapila
Tuberculous brain abscess(TBA)is a rare manifestation of CNS tuberculosis.Only a few cases have been reported in literature. A 26 year old male presented with high garde,throbbing headache and altered sensorium.Examination revealed neck stiffness and papilloedema.His chest Xray showed evidence of healed pulmonary tuberculosis.MRI brain showed a well circumscribed hyperintense lesion in the left parietal region with perilesional oedema and mass effects
Stereotactic aspiration of the abscees yielded frank creamy pus.PCR for Mycobacterium tubercculosis MPV64 was positive which confirmed the lesin to be of tuberculous aetiology.Patient responded well to four drug regimen of antitubercular treatment. Indian J Tuberc 2007,54,196-198
K.Sadacharam,PG.Gopi,V.Chandrasekaran,S.I.Eusuff,R.Subramani,Santha and P.R.Narayanan
Objective To describe the status of cases 2-3 years after the initiation of treatment undeer DOTS.
Setting After DOTS implementation in Tiruvallur district,South India ,We followed up a cohort of smear positive TB patients registered during 2002-2003 after initiation of treatment.
Results: The overall mortality rate was 15.0% and among the remaining 18.6% had active disease.In multivariate analysis, a higher mortality was independently associated with age,sex,occupation,treatment outcome and initial body weight of patients.
Conclusion: The mortality and morbidity rates are still high during follow up and needs to be curtailed by addressing these issues effectively in TB control programme. Indian J Tuberc 2007,54,199-203
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