Objectives
  • Disseminate info on TB in India
  • Improve care of TB patients in India
  • Enable doctors and NGO's interested in TB control to interact
Acceptable regimens in the presence of MDR TB(WHO recommendation)
Situation B:Susceptibility test results are available before starting the new treatment:
Resistance to isoniazid and rifampiccin (with or without resistance to streptomycin)
b. Resistance to isoniazid ,rifampicin,ethambutol(with or without resistance ot streptomycin)
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Resistance to Initial phase Continuation phase
Drugs Minimum
duration
in months 		Drugs Duration
in months
Isoniazid
rifampicin and
streptomycin 		1.aminoglycosidee
2.ethionamide
3.pyrazinamide
4.ofloxacinf
5.ethambutol 		3
3
3
3
3 		1.ethionamide
2.ofloxacin
3.cycloserine 		18
18
18
Isoniazid
rifampicin
streptomycin
and ethambutol 		1.aminoglycosidee
2.ethionamide
3.pyrazinamide
4.ofloxacin
5.cycloserineg		 3
3
3
3 		1.ethionamide
2.ofloxacin
3.cycloserine 		18
18
18
e)Kanamycin or amikacin or Capreomycin
f)The daily dose of 800mg can be reduced to 400mg if poorly tolerated
b)PAS,if cycloserine is not available or too toxic
c)Streptomycin ,if still active;if resistance to streptomycin,use Kannamycin or Capreomycin
d)if ethionamide is not available or poorly tolerated(even at a dose of 500 mg /day)use ofloxacin