Objectives
  • Disseminate info on TB in India
  • Improve care of TB patients in India
  • Enable doctors and NGO's interested in TB control to interact

Treatment of tuberculosis


Category of treatment
Type of patient
Regimen
CATEGORY I New sputum smearpositive 2(HRZE)3 4(HR)2
Seriously ill smear negative
Seriously ill extrapulmonary
Category II Sputum smear positive positive relapse 2(HRZES)3/1(HRZE)3/5(HRE)3
Sputum smear positive failure
Sputum smear positive treatment after default
Category III Sputumsmear negative not seriously ill 2(HRZ)3/4(HR)3

To help general practitioners to arrive at a decision on category for their case we have an online module.You will be asked to fill up some forms(site of lesion,sputum result etc)Then the treatment category and treatment will be shown
Click here

Categorywise sputum examination results and actions to be taken
Category of treatment Pretreatment sputum Test at month IF result is: THEN
Category I + 2 - Start continuation phase,test sputum again at 4 and 6 months
+ Continue intensive phase for one more month
- 2 - Start continuation phase,test sputum again at 6 months
+ Continue intensive phase for one more month,test sputum again at 3,4, and 7 months
Category II + 3 - Start continuation phase,test sputum again at 5 and 6 months
+ Continue intensive phase for one more month,test sputum again at 4,6 and 9 months
Category III - 2 - Start continuation phase,test sputum again 1t 6 months
+ Reregister the patient and begin Category II treatment

The number before the letters (eg 2(HRZE etc) refers to the number of months of treatment.The subscript after the letters refers to the number of doses per week.H:Isoniazid(600mg) Rifmapicin(450mg) Z:Pyrazinamide(1500mg).Patients who weigh more than 60Kg receive additional rifampicin 150 mg.Patients more than 50 years old receive Streptomycin 500mg.Patients in categories I and II who have positive sputum smear at the end of the initial intensive phase receive an additonal month of intensive treatment

Examples of seriously ill extrapulmonary cases are meningitis,disseminated TB,tuberculous pericarditis,peritonitis,,bilateral extensive pleurisy,spinal TB with neurological complications. and intestinal and genitourinary TB.

In rare and exceptional cases patients who are sputum smear negative or who have extrapulmonary disease can have relapse or failure.This diagnosis in all such cases should always be made by an MO and should be supported by culture or histological evidence of current active tuberculosis.In these cases,the patient should be categorized as "Other" and given Category II treatment.

Any patient treated with Category I or Category II who has a positive smear at 5,6, or 7 months of treatment should be considered a failure and started on Category II treatment afresh.

Phases and duration of treatment
Category
Duration(Number of doses)
Total
Intensive phase
Continuation phase
CAT I 8 weeks(24 doses) 18 weeks(54 doses) 26 weeks(78 doses)
CAT II 12 weeks(36 doses) 22 weeks(66 doses) 34 weeks(102 doses)
CAT III 8 weeks(24 doses) 18 weeks(54 doses) 26 weeks(78 doses)

Utility to find treatment category
Dosages and phamacokinetics of antitubercular drugs
Disclaimer Although every precaution has been taken in the preparation of this site,the author assumes no responsibility for errors or omisssions.Neither is any liability assumed for damages resulting from the use of the information contained herein