Indiana State Route 43 is a north-south highway in North-Central Tippecanoe County. It runs from the Tippecanoe/White County Line, near Ash Grove, to Lafayette. IN St Rt 43 passes through the following town in Tippecanoe County. Lafayette IN St Rt 43 is not multi-plexed in Tippecanoe County. IN St Rt 43 crosses the following highways in Tippecanoe County. Indiana State Route 225, near Battle Ground. Interstate 65, near Layfayette. U.S. Rt. 52, at Lafayette. (NO INTERCHANGE) Indiana State Route 443, at Lafayette. U.S. Rt. 231, at Lafayette.