U.S. Federal Route 52 is one of the main routes through the Layfayette-Tippecanoe County Highway system. This highway proviedes acces to the east and northsides of the Lafayette area. U.S. Rt. 52 passes through the following towns in Tippecanoe County. Monroe
Lafayette
Klondike Montmoreenci
U.S. Rt. 52 is multi-plexed in Tippecanoe County. Indiana State Route 28, near Clarks Hill.
EB U.S. Rt. 52 near the White River. WB U.S. Rt. 52 at Layfayette. WB U.S. Rt. 52 at U.S. Rt. 231 in Lafayette. A guide sign on NB U.S. Rt. 231 in Lafayette.