Indiana State Route 66 is one of several main east-west surface highways in the Evansville Area. IN St Rt 66 passes through the following town in Evansville. Evansville IN St Rt 66 is multi-plexed in Vanderburgh County. U.S. Rt. 41, at Evansville. Indiana State Route 62, at Evansville. IN St Rt 66 intersects the following highways in Vanderburgh County. Interstate 164, near Evansville. U.S. Rt. 41, at Evansville. Indiana State Route 62, at Evansville. Indiana State Route 65, near Kasson.
