U.S. Federal Route 150 runs east-west across Central Floyd County. It runs from the Floyd/Harrison County Line to the Indiana/Kentucky State Line. U.S. Rt. 150 passes through the following towns in Floyd County. Greenville Galena New Albany U.S. Rt. 150 is multi-plexed in Floyd County. Interstate 64, from near Floyds Knobs to the Indiana/Kentucky State Line.