Roads of the Mid-South & West > Highways of the State of Iowa > Iowa State Route 21
![](/rnb/bill21/ia21.JPG) | Iowa State Route 21 |
Iowa State Route 21 runs north-south in Central Iowa. This runs from Waterloo to near Ottumwa, via Iowa State Route 149, and U.S. Rt. 63.
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Keokuk County