Iowa State Route 21 runs north-south in Poweshiek County. This runs in the eastern portion of the county. IA St Rt 21 does not pass thorugh any towns in Poweshiek County. IA St Rt 21 is multi-plexed in Poweshiek County. U.S. Rt. 6, from the Iowa/Poweshiek County Line to near Victor.
IA St Rt 21 intersects the following highways in Poweshiek County. Former Iowa State Route 419, near Victor. U.S. Rt. 6, near Victor.
