Iowa State Route 2 is the main east-west highway in Central Lee County. This runs from the Mississippi River Bridge, at Fort Madison, to the Lee/Van Buren County Line, enar Farmington. IA St Rt 2 passes through the following towns in Lee County. Fort Madison
Donnelson IA St Rt 2 is multi-plexed in Lee County. U.S. Rt. 61, at Fort Madison.