U.S. Federal Route 61 is the main north-south highway in Eastern Lee County. This runs along the Mississippi River banks. It connects Fourt Madison and Keokuk to each other. U.S. Rt. 61 passes through the following towns in Lee County. Wever Fort Madison
Keokuk U.S. Rt. 61 is multi-plexed in Lee County. Iowa State Route 2, at Fort Madison.
U.S. Rt. 218, from near Montrose to Keokuk. U.S. Rt. 136, near Keokuk. U.S. Rt. 61 intersects the following highways in Lee County. Iowa State Route 16, near Wever.