U.S. Federal Route 45 is the main north-south highway in Central Clay County. It is also the only highway to pass through the founty seat of Clay County, Louisville. U.S. Rt. 45 passes through the following towns in Clay County. Hord
Louisville
Flora
U.S. Rt. 45 is multi-plexed in Clay County. U.S. Rt. 50, near Flora.
U.S. Rt. 45 intersects the following highways in Clay County. U.S. Rt. 50, near Flora.