Mississippi State Route 6 is a east-west highway in East-Central Coahoma County. It runs from Lyon to the Coahoma/Quitman County Line. MS St Rt 6 passes through the following town in Coahoma County. Lyon
MS St Rt 6 is multi-plexed in Coahoma County. U.S. Rt. 278, from near Lyon to the Coahoma/Quitman County Line.
A junction marker on SB MS St Rt 161. A BGS on NB U.S. Rt. 49/61; EB U.S. Rt. 278. EB U.S. Rt. 278/MS St Rt 6 east of U.S. Rt. 49/61. WB U.S. Rt. 278/MS St Rt 6 at the Coahoma/Quitman County Line.
