U.S. Federal Route 49 is a north-south highway in Coahoma County. This runs from the northwestern corner to near the southeastern corner of the county. It has one of the states Mississippi River crossings. U.S. Rt. 49 passes through the following towns in Coahoma County. Clarksdale Dublin U.S. Rt. 49 is multi-plexed in Coahoma County. U.S. Rt. 61, from near Rich to Clarksdale.