U.S. Federal Route 51 is a north-south highway in Central De Soto County. This runs along the westside of the Interstate 55 corridor. It provides traffic in the Greater-Memphis Area, a surface alternative to the interstate. U.S. Rt. 51 passes through the following towns in De Soto County. Southaven Horn Lake Hernando U.S. Rt. 51 is not multi-plexed in De Soto County. U.S. Rt. 51 intersects the following highways in De Soto County. Mississippi State Route 302, at Horn Lake.
